Home LiteratureArticle Details
PMID: 2954814 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Drosophila position-specific antigens resemble the vertebrate fibronectin-receptor family.

The EMBO journal ·Vol. 6 ·No. 4 ·1987-04-00 ·Pages 1037-43

Leptin M, Aebersold R, Wilcox M

Abstract

The Drosophila position-specific (PS) antigens are a family of cell surface glycoprotein complexes thought to be involved in morphogenesis. Their overall structures and biochemical properties are similar to those of a group of vertebrate receptors, including those for fibronectin, fibrinogen and vitronectin, and also the leukocyte antigens Mac-1, LFA-1 and p150,95 and the VLA family of cell surface antigens. The N-terminal sequences of the alpha subunits of some of these molecules are homologous to the N-terminus of a PS antigen component. The Drosophila PS antigens thus appear to be homologous to these vertebrate receptors.

MeSH Terms
Animals Antigens, Surface/genetics Cell Line Chymotrypsin Cyanogen Bromide Drosophila melanogaster/genetics Fibronectins/analysis Peptide Fragments/analysis Receptors, Fibronectin Receptors, Immunologic/genetics Sequence Homology, Nucleic Acid Vertebrates
Chemicals
Antigens, Surface Fibronectins Peptide Fragments Receptors, Fibronectin Receptors, Immunologic Chymotrypsin Cyanogen Bromide
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Leptin M
Aebersold R
Wilcox M
References (44)
44 references, click to expand
  1. Determination of blastoderm cells in Drosophila melanogaster.
    Proc Natl Acad Sci U S A. 1971 Sep;68(9):2217-21 PMID: 5002429
  2. Recombinant interleukin 4 promotes the growth of human T cells.
    J Immunol. 1987 Aug 15;139(4):1142-7 PMID: 3497196
  3. Control of compartment development by the engrailed gene in Drosophila.
    Nature. 1975 Jun 19;255(5510):614-7 PMID: 1134551
  4. Developmental compartmentalization in the dorsal mesothoracic disc of Drosophila.
    Dev Biol. 1976 Jan;48(1):132-47 PMID: 1245256
  5. Chemical characterisation of the Thy-1 glycoproteins from the membranes of rat thymocytes and brain.
    Nature. 1976 Oct 14;263(5578):563-7 PMID: 62283
  6. Peptide mapping of heterogeneous protein samples.
    J Biol Chem. 1979 Apr 25;254(8):2565-7 PMID: 429300
  7. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.
    Proc Natl Acad Sci U S A. 1979 Sep;76(9):4350-4 PMID: 388439
  8. Phase separation of integral membrane proteins in Triton X-114 solution.
    J Biol Chem. 1981 Feb 25;256(4):1604-7 PMID: 6257680
  9. Glycoproteins of platelet membranes from Glanzmann's thrombasthenia. A comparison with normal using carbohydrate-specific or protein-specific labelling techniques and high-resolution two-dimensional gel electrophoresis.
    Eur J Biochem. 1981 May 15;116(2):379-88 PMID: 7195813
  10. A gas-liquid solid phase peptide and protein sequenator.
    J Biol Chem. 1981 Aug 10;256(15):7990-7 PMID: 7263636
  11. A position-specific cell surface antigen in the drosophila wing imaginal disc.
    Cell. 1981 Jul;25(1):159-64 PMID: 6791831
  12. Differential glycosylation of murine B cell and spleen adherent cell Ia antigens.
    J Immunol. 1981 Oct;127(4):1478-84 PMID: 6792276
  13. Clonal analysis of the undifferentiated wing disk of Drosophila.
    Dev Biol. 1981 Sep;86(2):448-55 PMID: 7286408
  14. Differences in the carbohydrate structures of neural cell-adhesion molecules from adult and embryonic chicken brains.
    J Biol Chem. 1982 Sep 25;257(18):11064-9 PMID: 6809766
  15. Identification of concanavalin A-binding proteins after sodium dodecyl sulfate--gel electrophoresis and protein blotting.
    Anal Biochem. 1982 Jun;123(1):143-6 PMID: 7114467
  16. Cell surface molecules and fibronectin-mediated cell adhesion: effect of proteolytic digestion of membrane proteins.
    J Cell Biol. 1982 Jul;94(1):179-86 PMID: 6749866
  17. endo-beta-N-acetylglucosaminidase F: endoglycosidase from Flavobacterium meningosepticum that cleaves both high-mannose and complex glycoproteins.
    Proc Natl Acad Sci U S A. 1982 Aug;79(15):4540-4 PMID: 6812050
  18. Analysis of phenylthiohydantoins by ultrasensitive gradient high-performance liquid chromatography.
    Methods Enzymol. 1983;91:486-93 PMID: 6855596
  19. A human leukocyte differentiation antigen family with distinct alpha-subunits and a common beta-subunit: the lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1), and the p150,95 molecule.
    J Exp Med. 1983 Dec 1;158(6):1785-1803 PMID: 6196430
  20. Posterior-to-anterior transformation in engrailed wing imaginal disks of Drosophila.
    Nature. 1984 Aug 9-15;310(5977):496-7 PMID: 6431298
  21. Cell migrations in embryos.
    Cell. 1984 Sep;38(2):353-60 PMID: 6467371
  22. Biologically active synthetic peptides as probes of embryonic development: a competitive peptide inhibitor of fibronectin function inhibits gastrulation in amphibian embryos and neural crest cell migration in avian embryos.
    J Cell Biol. 1984 Nov;99(5):1822-30 PMID: 6490722
  23. The Drosophila position-specific antigens are a family of cell surface glycoprotein complexes.
    EMBO J. 1984 Oct;3(10):2307-13 PMID: 6499831
  24. Related cell-surface antigens expressed with positional specificity in Drosophila imaginal discs.
    Proc Natl Acad Sci U S A. 1984 Dec;81(23):7485-9 PMID: 6390440
  25. Cleavage of a 135 kD cell surface glycoprotein correlates with loss of fibroblast adhesion to fibronectin.
    Exp Cell Res. 1985 Jan;156(1):182-90 PMID: 2981173
  26. A monoclonal antibody identifies a glycoprotein complex involved in cell-substratum adhesion.
    Exp Cell Res. 1985 Mar;157(1):218-26 PMID: 2578969
  27. Developmental analysis of Drosophila position-specific antigens.
    Dev Biol. 1985 Mar;108(1):120-30 PMID: 3918898
  28. Sequence homology of the LFA-1 and Mac-1 leukocyte adhesion glycoproteins and unexpected relation to leukocyte interferon.
    Nature. 1985 Apr 11-17;314(6011):540-2 PMID: 3887182
  29. Selective inhibition of fibronectin-mediated cell adhesion by monoclonal antibodies to a cell-surface glycoprotein.
    Science. 1985 Jun 21;228(4706):1448-51 PMID: 4012302
  30. Interaction of fibronectin with its receptor on platelets.
    Cell. 1985 Sep;42(2):439-48 PMID: 2411420
  31. A 125/115-kDa cell surface receptor specific for vitronectin interacts with the arginine-glycine-aspartic acid adhesion sequence derived from fibronectin.
    Proc Natl Acad Sci U S A. 1985 Sep;82(17):5766-70 PMID: 2412224
  32. Characterization of a membrane-associated glycoprotein complex implicated in cell adhesion to fibronectin.
    J Cell Biochem. 1985;28(4):307-18 PMID: 4055919
  33. Biochemical and functional characteristics of the human leukocyte membrane antigen family LFA-1, Mo-1 and p150,95.
    Eur J Immunol. 1985 Nov;15(11):1142-8 PMID: 2933266
  34. The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to platelets.
    Proc Natl Acad Sci U S A. 1985 Dec;82(23):8057-61 PMID: 3877935
  35. Characterization of a 140-kD avian cell surface antigen as a fibronectin-binding molecule.
    J Cell Biol. 1986 Feb;102(2):442-8 PMID: 2935540
  36. The fibronectin receptor on mammalian erythroid precursor cells: characterization and developmental regulation.
    J Cell Biol. 1986 Feb;102(2):449-56 PMID: 2935541
  37. Arg-Gly-Asp: a versatile cell recognition signal.
    Cell. 1986 Feb 28;44(4):517-8 PMID: 2418980
  38. Electroblotting onto activated glass. High efficiency preparation of proteins from analytical sodium dodecyl sulfate-polyacrylamide gels for direct sequence analysis.
    J Biol Chem. 1986 Mar 25;261(9):4229-38 PMID: 3949810
  39. Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin.
    Cell. 1986 Jul 18;46(2):271-82 PMID: 3487386
  40. The growing immunoglobulin gene superfamily.
    Nature. 1986 Sep 4-10;323(6083):15-6 PMID: 3748173
  41. cDNA and amino acid sequences of the cell adhesion protein receptor recognizing vitronectin reveal a transmembrane domain and homologies with other adhesion protein receptors.
    Proc Natl Acad Sci U S A. 1986 Nov;83(22):8614-8 PMID: 2430295
  42. Cell-surface receptors: puzzles and paradigms.
    Bioessays. 1986 Apr;4(4):149-51 PMID: 3024638
  43. Peptides containing the cell-attachment recognition signal Arg-Gly-Asp prevent gastrulation in Drosophila embryos.
    Nature. 1987 Jan 22-28;325(6102):348-50 PMID: 3100959
  44. High resolution two-dimensional electrophoresis of proteins.
    J Biol Chem. 1975 May 25;250(10):4007-21 PMID: 236308
Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1987-04-00
Pages
1037-43
Language
English
Region
England
NLM ID
8208664
PMCID
PMC553500
Subset
IM
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2