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PMID: 2950135 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Prostaglandin E1 inhibits effector T cell induction and tissue damage in experimental murine interstitial nephritis.

The Journal of clinical investigation ·Vol. 79 ·No. 3 ·1987-03-00 ·Pages 782-9

Kelly CJ, Zurier RB, Krakauer KA, Blanchard N, Neilson EG

Abstract

Immunosuppressive effects of E-series prostaglandins have been demonstrated in many in vitro assays of immune responsiveness as well as in autoimmune diseases. To explore the mechanisms underlying prostaglandin E1 (PGE1)-associated immunosuppression in autoimmunity, we treated SJL mice immunized to produce immune-mediated interstitial nephritis with PGE1, PGF2 alpha, or vehicle alone. Mice receiving PGE1 treatment do not develop interstitial nephritis, nor do they display delayed-type hypersensitivity (DTH) to the immunizing renal tubular antigen preparation. The observed immunosuppression is critically dependent on PGE1 administration during the period of effector T cell induction. We therefore investigated the effect of PGE1 on the in vitro induction of DTH effector T cells reactive to renal tubular antigens (SRTA). PGE1 inhibits effector T cell induction in a dose-dependent, reversible manner, but has no inhibitory effect on fully differentiated DTH effector cells or SRTA-reactive cell lines. The PGE1 effect is indirect and mediated via nonspecific suppressor lymphokines. This suppression can be overcome by recombinant interleukin 1 (IL-1), which suggests a mechanism related to either diminished IL-1 secretion or target cell sensitivity to IL-1.

MeSH Terms
Alprostadil/therapeutic use Animals Antigens/immunology Autoimmune Diseases/drug therapy,immunology Basement Membrane/immunology Dinoprost Hypersensitivity, Delayed/immunology Immunization Interleukin-1/physiology Kidney Tubules/immunology Mice Nephritis, Interstitial/immunology,pathology,prevention & control Prostaglandins F/pharmacology Rabbits Recombinant Proteins T-Lymphocytes/immunology T-Lymphocytes, Helper-Inducer/immunology
Chemicals
Antigens Interleukin-1 Prostaglandins F Recombinant Proteins Dinoprost Alprostadil
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Kelly C J
Zurier R B
Krakauer K A
Blanchard N
Neilson E G
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34 references, click to expand
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI112885
Published
1987-03-00
Pages
782-9
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC424199
Subset
IM
Grants
NIADDK NIH HHS · AM-07006 · United States
NIADDK NIH HHS · AM-20553 · United States
NIADDK NIH HHS · AM-30280 · United States
External Links
PubMed source DOI: 10.1172/JCI112885 PMC Full Text View journal details
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