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PMID: 2415658 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Tolerance to parenchymal self. Regulatory role of major histocompatibility complex-restricted, OX8+ suppressor T cells specific for autologous renal tubular antigen in experimental interstitial nephritis.

The Journal of experimental medicine ·Vol. 162 ·No. 6 ·1985-12-01 ·Pages 1892-903

Kelly CJ, Silvers WK, Neilson EG

Abstract

BN rats develop interstitial nephritis after immunization with rabbit, but not rat renal tubular antigen. Using RT1n rat strains that differentially express tubular antigen, we investigated the unresponsiveness of BN rats to BN tubular antigen (BN-TBM) using delayed-type hypersensitivity (DTH) responses to BN-TBM as a measure of cell-mediated immunity. Our results indicate that rat strains expressing tubular antigen respond to immunization with BN-TBM with the clonal expansion of antigen-specific, cyclophosphamide-sensitive, OX8+, MHC-restricted suppressor T cells. Such suppression appears to be relevant to the maintenance of tolerance to parenchymal self, since chronic cyclophosphamide therapy abrogates suppression and results in significant interstitial nephritis.

MeSH Terms
Animals Antigens/genetics,immunology Autoantigens/genetics,immunology Basement Membrane/immunology Epitopes Histocompatibility Antigens/genetics,immunology Hypersensitivity, Delayed/genetics Immune Tolerance Kidney Tubules/immunology Nephritis, Interstitial/etiology,genetics,immunology Phenotype Rats Rats, Inbred BN Rats, Inbred Lew Species Specificity T-Lymphocytes, Regulatory/classification,immunology
Chemicals
Antigens Autoantigens Epitopes Histocompatibility Antigens histocompatibility antigens RT, rat renal tubular antigen
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kelly C J
Silvers W K
Neilson E G
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33 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.162.6.1892
Published
1985-12-01
Pages
1892-903
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2187971
Subset
IM
Grants
NIADDK NIH HHS · AM-07006 · United States
NIADDK NIH HHS · AM-20553 · United States
NIADDK NIH HHS · AM-30280 · United States
External Links
PubMed source DOI: 10.1084/jem.162.6.1892 PMC Full Text View journal details
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