Abstract
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma, which shows high aggressiveness and lacks biomarkers. RhoB acts as a tumor suppressor that inhibits the progression of ccRCC. In the present study, we examined the effects of oncogenic microRNAs, miR-19a and miR-19b, on RhoB expression in ccRCC cells. The results showed that both miR-19a and miR-19b could directly target the 3'untranslated region (3'UTR) of RhoB, resulting in the reduced expression of RhoB. With RT-PCR analysis, we detected the increased expression of miR-19a and miR-19b in ccRCC tissues compared to adjacent non-tumor renal tissues. These data also demonstrated an exclusive negative correlation between miR-19a/19b and RhoB expression in ccRCC specimens and cell lines. In addition, the knockdown of RhoB or overexpression of miR-19a and miR-19b in ccRCC cells could promote cell proliferation, migration and invasion. These data demonstrate the direct roles of miR-19a and miR-19b on the repression of RhoB and its consequences on tumorigenesis, cancer cell proliferation and invasiveness. These results suggest the potential clinical impact of miR-19a and miR-19b as molecular targets for ccRCC.
MeSH Terms
3' Untranslated Regions
Apoptosis/genetics
Carcinoma, Renal Cell/genetics,pathology
Cell Line, Tumor
Cell Proliferation
Gene Knockdown Techniques
Humans
Kidney Neoplasms/genetics,pathology
MicroRNAs/genetics
Middle Aged
Neoplasm Invasiveness
Neoplasm Metastasis
Real-Time Polymerase Chain Reaction
rhoB GTP-Binding Protein/genetics,metabolism
Chemicals
3' Untranslated Regions
MIRN19 microRNA, human
MicroRNAs
rhoB GTP-Binding Protein
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Niu Shaoxi
Department of Urology/State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital/Chinese PLA Medical Academy, Beijing, People's Republic of China. | Department of Pathology, Duke University, Durham, North Carolina, United States of America.
Ma Xin
Department of Urology/State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital/Chinese PLA Medical Academy, Beijing, People's Republic of China.
Zhang Yu
Department of Urology/State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital/Chinese PLA Medical Academy, Beijing, People's Republic of China.
Liu Yen-Nien
Department of Pathology, Duke University, Durham, North Carolina, United States of America. | Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Chen Xufeng
Department of Pathology, Duke University, Durham, North Carolina, United States of America.
Gong Huijie
Department of Urology/State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital/Chinese PLA Medical Academy, Beijing, People's Republic of China. | Department of Urology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, People's Republic of China.
Yao Yuanxin
Department of Urology/State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital/Chinese PLA Medical Academy, Beijing, People's Republic of China.
Liu Kan
Department of Urology/State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital/Chinese PLA Medical Academy, Beijing, People's Republic of China.
Zhang Xu
ORCID
Department of Urology/State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital/Chinese PLA Medical Academy, Beijing, People's Republic of China.
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