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PMID: 29474434 Published · epublish English Journal Article Research Support, Non-U.S. Gov't

MicroRNA-19a and microRNA-19b promote the malignancy of clear cell renal cell carcinoma through targeting the tumor suppressor RhoB.

PloS one ·Vol. 13 ·No. 2 ·2018-00-00 ·Pages e0192790

Niu S, Ma X, Zhang Y, Liu YN, Chen X, Gong H, Yao Y, Liu K, Zhang X

Abstract

Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma, which shows high aggressiveness and lacks biomarkers. RhoB acts as a tumor suppressor that inhibits the progression of ccRCC. In the present study, we examined the effects of oncogenic microRNAs, miR-19a and miR-19b, on RhoB expression in ccRCC cells. The results showed that both miR-19a and miR-19b could directly target the 3'untranslated region (3'UTR) of RhoB, resulting in the reduced expression of RhoB. With RT-PCR analysis, we detected the increased expression of miR-19a and miR-19b in ccRCC tissues compared to adjacent non-tumor renal tissues. These data also demonstrated an exclusive negative correlation between miR-19a/19b and RhoB expression in ccRCC specimens and cell lines. In addition, the knockdown of RhoB or overexpression of miR-19a and miR-19b in ccRCC cells could promote cell proliferation, migration and invasion. These data demonstrate the direct roles of miR-19a and miR-19b on the repression of RhoB and its consequences on tumorigenesis, cancer cell proliferation and invasiveness. These results suggest the potential clinical impact of miR-19a and miR-19b as molecular targets for ccRCC.

MeSH Terms
3' Untranslated Regions Apoptosis/genetics Carcinoma, Renal Cell/genetics,pathology Cell Line, Tumor Cell Proliferation Gene Knockdown Techniques Humans Kidney Neoplasms/genetics,pathology MicroRNAs/genetics Middle Aged Neoplasm Invasiveness Neoplasm Metastasis Real-Time Polymerase Chain Reaction rhoB GTP-Binding Protein/genetics,metabolism
Chemicals
3' Untranslated Regions MIRN19 microRNA, human MicroRNAs rhoB GTP-Binding Protein
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Niu Shaoxi
Department of Urology/State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital/Chinese PLA Medical Academy, Beijing, People's Republic of China. | Department of Pathology, Duke University, Durham, North Carolina, United States of America.
Ma Xin
Department of Urology/State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital/Chinese PLA Medical Academy, Beijing, People's Republic of China.
Zhang Yu
Department of Urology/State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital/Chinese PLA Medical Academy, Beijing, People's Republic of China.
Liu Yen-Nien
Department of Pathology, Duke University, Durham, North Carolina, United States of America. | Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Chen Xufeng
Department of Pathology, Duke University, Durham, North Carolina, United States of America.
Gong Huijie
Department of Urology/State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital/Chinese PLA Medical Academy, Beijing, People's Republic of China. | Department of Urology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, People's Republic of China.
Yao Yuanxin
Department of Urology/State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital/Chinese PLA Medical Academy, Beijing, People's Republic of China.
Liu Kan
Department of Urology/State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital/Chinese PLA Medical Academy, Beijing, People's Republic of China.
Zhang Xu ORCID
Department of Urology/State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital/Chinese PLA Medical Academy, Beijing, People's Republic of China.
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Article Info
Journal
PloS one
Abbr.
PLoS One
ISSN
1932-6203
Published
2018-00-00
Epub
2018-00-23
Pages
e0192790
Language
English
Region
United States
NLM ID
101285081
PMCID
PMC5825063
Subset
IM
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