Actin' up: RhoB in cancer and apoptosis.

Nature reviews. Cancer ·Vol. 1 ·No. 2 ·2001-00-00 ·Pages 162-8

Prendergast GC

Abstract

RhoB is a small GTPase that regulates actin organization and vesicle transport. It is required for signalling apoptosis in transformed cells that are exposed to farnesyltransferase inhibitors, DNA-damaging agents or taxol. Genetic analysis in mice indicates that RhoB is dispensable for normal cell physiology, but that it has a suppressor or negative modifier function in stress-associated processes, including cancer.

MeSH Terms

Actins/metabolism Alkyl and Aryl Transferases/antagonists & inhibitors,physiology Animals Antineoplastic Agents/pharmacology Apoptosis/physiology Cell Adhesion/physiology Cell Division/physiology DNA Damage Enzyme Induction Enzyme Inhibitors/pharmacology Farnesyltranstransferase Guanosine Triphosphate/metabolism Humans Mice Multigene Family Neoplasm Proteins/antagonists & inhibitors,physiology Neoplasms/genetics,metabolism,pathology Paclitaxel/pharmacology Protein Prenylation/drug effects Protein Processing, Post-Translational/drug effects Signal Transduction/physiology Stress, Physiological/genetics,metabolism ras Proteins/antagonists & inhibitors rhoB GTP-Binding Protein/physiology

Chemicals

Actins Antineoplastic Agents Enzyme Inhibitors Neoplasm Proteins Guanosine Triphosphate Alkyl and Aryl Transferases geranylgeranyltransferase type-I Farnesyltranstransferase ras Proteins rhoB GTP-Binding Protein Paclitaxel

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Prendergast G C

The DuPont Pharmaceuticals Company, Glenolden Laboratory, Pennsylvania 19004, USA. george.c.prendergast@dupontpharma.com

Article Info

Journal

Nature reviews. Cancer

Abbr.

Nat Rev Cancer

ISSN

1474-175X

DOI

10.1038/35101096

george.c.prendergast@dupontpharma.com

Published

2001-00-00

Pages

162-8

Language

English

Region

England

NLM ID

101124168

Subset

External Links

PubMed source DOI: 10.1038/35101096 View journal details

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Actin' up: RhoB in cancer and apoptosis.

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