Prolactin as a modulator of lymphocyte responsiveness provides a possible mechanism of action for cyclosporine.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 83 ·No. 8 ·1986-04-00 ·Pages 2599-603

Hiestand PC, Mekler P, Nordmann R, Grieder A, Permmongkol C

Abstract

Lymphocyte responsiveness in rats was found to depend on serum prolactin levels. Blocking pituitary prolactin release with bromocriptine severely reduces lymphocyte reactivity in vitro (mixed lymphocyte reaction) as well as in vivo (graft-versus-host reaction). In addition, evidence for a prolactin/growth hormone-related mRNA species produced in mitogen- and antigen-stimulated lymphocytes has been obtained. Prolactin was shown to compete in a dose-dependent fashion with the immunosuppressant cyclosporine (cyclosporin A) for a common binding site on the surface of T lymphocytes. Further, stimulation of prolactin secretion reversed the immunosuppression induced by cyclosporine. We conclude that prolactin is involved in the maintenance of T-cell immunocompetence and that the immunosuppressive effects of cyclosporine may be mediated by the displacement of prolactin from binding sites on lymphocytes.

MeSH Terms

Animals Antibody Formation/drug effects Binding, Competitive Cyclosporins/pharmacology Female Flow Cytometry Graft vs Host Reaction Hemolytic Plaque Technique Lymphocyte Activation Lymphocyte Cooperation/drug effects Lymphocyte Culture Test, Mixed Lymphocytes/drug effects,immunology Mice Prolactin/physiology Rats

Chemicals

Cyclosporins Prolactin

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Hiestand P C

Mekler P

Nordmann R

Grieder A

Permmongkol C

References (17)

17 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.83.8.2599

Published

1986-04-00

Pages

2599-603

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC323346

Subset

External Links

PubMed source DOI: 10.1073/pnas.83.8.2599 PMC Full Text View journal details

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Prolactin as a modulator of lymphocyte responsiveness provides a possible mechanism of action for cyclosporine.

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