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PMID: 29312327 Published · epublish English Journal Article Review

Tertiary Lymphoid Structures in Cancer: Drivers of Antitumor Immunity, Immunosuppression, or Bystander Sentinels in Disease?

Frontiers in immunology ·Vol. 8 ·2017-00-00 ·Pages 1830

Colbeck EJ, Ager A, Gallimore A, Jones GW

Abstract

Secondary lymphoid organs are integral to initiation and execution of adaptive immune responses. These organs provide a setting for interactions between antigen-specific lymphocytes and antigen-presenting cells recruited from local infected or inflamed tissues. Secondary lymphoid organs develop as a part of a genetically preprogrammed process during embryogenesis. However, organogenesis of secondary lymphoid tissues can also be recapitulated in adulthood during de novo lymphoid neogenesis of tertiary lymphoid structures (TLSs). These ectopic lymphoid-like structures form in the inflamed tissues afflicted by various pathological conditions, including cancer, autoimmunity, infection, or allograft rejection. Studies are beginning to shed light on the function of such structures in different disease settings, raising important questions regarding their contribution to progression or resolution of disease. Data show an association between the tumor-associated TLSs and a favorable prognosis in various types of human cancer, attracting the speculation that TLSs support effective local antitumor immune responses. However, definitive evidence for the role for TLSs in fostering immune responses in vivo are lacking, with current data remaining largely correlative by nature. In fact, some more recent studies have even demonstrated an immunosuppressive, tumor-promoting role for cancer-associated TLSs. In this review, we will discuss what is known about the development of cancer-associated TLSs and the current understanding of their potential role in the antitumor immune response.

Keywords
cancer immunotherapy high endothelial venules lymphoid neogenesis tertiary lymphoid structures tumor microenvironment
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Colbeck Emily Jayne
UCL Cancer Institute, University College London, London, United Kingdom.
Ager Ann
Division of Infection and Immunity, School of Medicine and Systems Immunity Research Institute, Cardiff University, Cardiff, United Kingdom.
Gallimore Awen
Division of Infection and Immunity, School of Medicine and Systems Immunity Research Institute, Cardiff University, Cardiff, United Kingdom.
Jones Gareth Wyn
Division of Infection and Immunity, School of Medicine and Systems Immunity Research Institute, Cardiff University, Cardiff, United Kingdom.
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Article Info
Journal
Frontiers in immunology
Abbr.
Front Immunol
ISSN
1664-3224
DOI
10.3389/fimmu.2017.01830
Published
2017-00-00
Epub
2017-00-19
Pages
1830
Language
English
Region
Switzerland
NLM ID
101560960
PMCID
PMC5742143
Grants
Wellcome Trust · United Kingdom
Arthritis Research UK · 20305 · United Kingdom
Versus Arthritis · 20305 · United Kingdom
Medical Research Council · MR/L008742/1 · United Kingdom
External Links
PubMed source DOI: 10.3389/fimmu.2017.01830 PMC Full Text View journal details
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