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PMID: 2928321 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Identification and sequence analysis of a second form of prolactin receptor by molecular cloning of complementary DNA from rabbit mammary gland.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 86 ·No. 6 ·1989-03-00 ·Pages 2112-6

Edery M, Jolicoeur C, Levi-Meyrueis C, Dusanter-Fourt I, Pétridou B, Boutin JM, Lesueur L, Kelly PA, Djiane J

Abstract

Two lambda gt11 clones containing fragments of cDNA encoding the prolactin receptor from rabbit mammary gland were isolated using a rat liver prolactin receptor cDNA probe. An 1848-base-pair open reading frame encodes a mature prolactin-binding protein of 592 amino acids that contains three domains: (i) the extracellular, amino-terminal, prolactin-binding region of 210 residues; (ii) the transmembrane region of 24 residues; and (iii) the intracellular, carboxyl-terminal domain of 358 residues. This latter domain is much longer than the cytoplasmic domain (57 residues) previously described for the rat liver prolactin receptor. In addition, the sequence identity of this form of prolactin receptor with the growth hormone receptor is extended in the cytoplasmic domain.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Binding Sites Cell Line Cell Membrane/metabolism Cloning, Molecular DNA/genetics DNA Probes Female Gene Expression Regulation Glycosylation Liver/analysis Mammary Glands, Animal/analysis Molecular Sequence Data Nucleic Acid Hybridization Pregnancy Prolactin/metabolism Rabbits Rats Receptors, Prolactin/genetics Sequence Homology, Nucleic Acid Transfection
Chemicals
DNA Probes Receptors, Prolactin Prolactin DNA
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Edery M
Unité d'Endocrinologie Moléculaire, Institut National de la Recherche Agronomique, Jouy-en-Josas, France.
Jolicoeur C
Levi-Meyrueis C
Dusanter-Fourt I
Pétridou B
Boutin J M
Lesueur L
Kelly P A
Djiane J
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.86.6.2112
Published
1989-03-00
Pages
2112-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC286858
Subset
IM
Databases
GENBANK
J04510
External Links
PubMed source DOI: 10.1073/pnas.86.6.2112 PMC Full Text View journal details
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