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PMID: 291956 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Induction of acetylcholine receptors on cultured skeletal muscle by a factor extracted from brain and spinal cord.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 76 ·No. 10 ·1979-10-00 ·Pages 5397-401

Jessell TM, Siegel RE, Fischbach GD

Abstract

Extracts of chicken brain and spinal cord increase the total number of acetylcholine receptors and the number of acetylcholine receptors and the number of receptor clusters on uninnervated skeletal myotubes in culture. The active component in these extracts may be unique to neural tissue. Spinal cord cells grown in culture contain the active factor and they secrete it into the medium. Most of the activity is associated with a small molecule possibly a peptide. Such a factor may be responsible for the clustering of receptors at newly formed nerve-muscle synapses.

MeSH Terms
Acetylcholine/metabolism Animals Brain/physiology Bungarotoxins/metabolism Cells, Cultured Chick Embryo Chickens Kinetics Muscles/drug effects,metabolism Receptors, Cholinergic/drug effects,physiology Spinal Cord/physiology Tissue Extracts/pharmacology
Chemicals
Bungarotoxins Receptors, Cholinergic Tissue Extracts Acetylcholine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Jessell T M
Siegel R E
Fischbach G D
References (32)
32 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.76.10.5397
Published
1979-10-00
Pages
5397-401
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC413150
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.76.10.5397 PMC Full Text View journal details
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