Regulation of muscle acetylcholine sensitivity by muscle activity in cell culture.

Science (New York, N.Y.) ·Vol. 181 ·No. 4094 ·1973-07-06 ·Pages 76-8

Cohen SA, Fischbach GD

Abstract

Muscle in tissue culture provides a good system for studying longterm changes in surface membrane acetylcholine sensitivity. Muscle fibers stimulated intermittently over prolonged periods are less sensitive to iontophoretically applied acetylcholine and bind less (125)I-labeled alpha-bungarotoxin than inactive fibers.

MeSH Terms

Acetylcholine/pharmacology Action Potentials/drug effects Animals Bungarotoxins/metabolism Cells, Cultured Chick Embryo Electric Stimulation Iodine Isotopes Iontophoresis Muscle Contraction Muscle Denervation Muscles/drug effects,metabolism Tetrodotoxin/pharmacology

Chemicals

Bungarotoxins Iodine Isotopes Tetrodotoxin Acetylcholine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Cohen S A

Fischbach G D

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.181.4094.76

Published

1973-07-06

Pages

76-8

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.181.4094.76 View journal details

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