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PMID: 2905023 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Activation and repression of transcription by homoeodomain-containing proteins that bind a common site.

Nature ·Vol. 336 ·No. 6201 ·1988-00-00 ·Pages 744-9

Jaynes JB, O'Farrell PH

Abstract

The product of the fushi tarazu (ftz) gene is shown to be a site-dependent activator of transcription. In vitro-defined binding sites act as ftz-dependent enhancers in cultured cells. Another homoeodomain-containing protein, the engrailed gene product, competes for homoeodomain-binding sites and counteracts ftz activation.

MeSH Terms
Animals Binding Sites Cells, Cultured Drosophila melanogaster/embryology,genetics Gene Expression Regulation Genes, Homeobox Genes, Regulator Insect Hormones Plasmids Transcription, Genetic
Chemicals
Insect Hormones
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Jaynes J B
Department of Biochemistry and Biophysics, University of California, San Francisco 94143.
O'Farrell P H
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Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/336744a0
Published
1988-00-00
Pages
744-9
Language
English
Region
England
NLM ID
0410462
PMCID
PMC2868829
Subset
IM
Grants
NIGMS NIH HHS · R01 GM037193 · United States
NIGMS NIH HHS · R01 GM037193-10 · United States
External Links
PubMed source DOI: 10.1038/336744a0 PMC Full Text View journal details
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