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PMID: 2898782 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Hox-5.1 defines a homeobox-containing gene locus on mouse chromosome 2.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 85 ·No. 13 ·1988-07-00 ·Pages 4760-4

Featherstone MS, Baron A, Gaunt SJ, Mattei MG, Duboule D

Abstract

We have isolated a murine homeobox-containing gene, Hox-5.1, by virtue of its relatedness to the Hox-1.4 gene. In situ hybridization to metaphase spreads mapped Hox-5.1 to band D of mouse chromosome 2. Sequence comparisons indicate that Hox-5.1 is the murine homolog of the human C13 homeobox-containing gene. Hox-5.1 also bears significant similarity to the Xenopus Xhox-1A homeobox-containing gene and the Drosophila deformed homeotic gene at N-terminal and homeobox regions. Hox-5.1 transcripts were detected in mouse embryos, in adult mouse testis, kidney, heart, and intestine, and in mouse embryonal carcinoma cells treated with retinoic acid. In situ hybridization to sections from whole mouse embryos revealed Hox-5.1 expression in spinal cord and prevertebrae.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Chromosome Mapping DNA/genetics Genes, Homeobox Humans Mice/genetics Molecular Sequence Data Sequence Homology, Nucleic Acid Species Specificity
Chemicals
DNA
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Featherstone M S
Laboratoire de Génétique Moléculaire des Eucaryotes, Unité 184 de l'Institut National de la Santé et de la Recherche Médicale, Faculté de Médicine, Strasbourg, France.
Baron A
Gaunt S J
Mattei M G
Duboule D
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.85.13.4760
Published
1988-07-00
Pages
4760-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC280515
Subset
IM
Databases
GENBANK
J03770
External Links
PubMed source DOI: 10.1073/pnas.85.13.4760 PMC Full Text View journal details
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