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PMID: 2878803 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Genetic and cytogenetic localisation of the homeo box containing genes on mouse chromosome 6 and human chromosome 7.

The EMBO journal ·Vol. 5 ·No. 11 ·1986-11-00 ·Pages 2899-905

Bućan M, Yang-Feng T, Colberg-Poley AM, Wolgemuth DJ, Guenet JL, Francke U, Lehrach H

Abstract

Probes from the m6 homeo box cluster were mapped to mouse chromosome 6 by somatic cell genetics, in situ hybridisation, and by a Mus spretus--Mus musculus backcross mapping system. In addition, the testis-specific homeo box containing cDNA, clone, HBT-1, has been mapped using the same back-cross system and the B X D recombinant inbred strain set. Close genetic and physical linkage between the m6 cluster and HBT-1 was demonstrated, positioning these sequences to the same local cluster of homeo box containing genes. The map location of this cluster between IgK and Tcrb coincides with the morphological mutation hypodactyly (Hd). Synteny has been observed between a region of mouse chromosome 6 and the long arm of human chromosome 7 encompassing the markers Cpa, Tcrb and Try-1. Here we localise human sequences hybridising to the mouse m6 probes to the short arm of chromosome 7, breaking the region of synteny.

MeSH Terms
Animals Chromosome Mapping Chromosomes, Human, Pair 7 Cricetinae Cricetulus Crosses, Genetic Female Genes, Homeobox Humans Hybrid Cells/cytology Male Mice Muridae Nucleic Acid Hybridization Recombination, Genetic Species Specificity
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Bućan M
Yang-Feng T
Colberg-Poley A M
Wolgemuth D J
Guenet J L
Francke U
Lehrach H
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1986-11-00
Pages
2899-905
Language
English
Region
England
NLM ID
8208664
PMCID
PMC1167240
Subset
IM
Grants
NIGMS NIH HHS · GM 26105 · United States
PHS HHS · R01 18122 · United States
External Links
PubMed source PMC Full Text View journal details
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