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PMID: 28851722 Published · ppublish English Journal Article Review Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Microtubule organization, dynamics and functions in differentiated cells.

Development (Cambridge, England) ·Vol. 144 ·No. 17 ·2017-00-01 ·Pages 3012-3021

Muroyama A, Lechler T

Abstract

Over the past several decades, numerous studies have greatly expanded our knowledge about how microtubule organization and dynamics are controlled in cultured cells in vitro However, our understanding of microtubule dynamics and functions in vivo, in differentiated cells and tissues, remains under-explored. Recent advances in generating genetic tools and imaging technologies to probe microtubules in situ, coupled with an increased interest in the functions of this cytoskeletal network in differentiated cells, are resulting in a renaissance. Here, we discuss the lessons learned from such approaches, which have revealed that, although some differentiated cells utilize conserved strategies to remodel microtubules, there is considerable diversity in the underlying molecular mechanisms of microtubule reorganization. This highlights a continued need to explore how differentiated cells regulate microtubule geometry in vivo.

Keywords
Centrosome Differentiation Microtubule Nucleation
MeSH Terms
Animals Cell Differentiation Centrosome/metabolism Humans Microtubule-Organizing Center/metabolism Microtubules/metabolism Models, Biological
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Muroyama Andrew
Departments of Dermatology and Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.
Lechler Terry ORCID
Departments of Dermatology and Cell Biology, Duke University Medical Center, Durham, NC 27710, USA terry.lechler@duke.edu.
Conflict of Interest

Competing interestsThe authors declare no competing or financial interests.

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Article Info
Journal
Development (Cambridge, England)
Abbr.
Development
ISSN
1477-9129
DOI
10.1242/dev.153171
Email
terry.lechler@duke.edu
Published
2017-00-01
Pages
3012-3021
Language
English
Region
England
NLM ID
8701744
PMCID
PMC5611961
Subset
IM
Grants
NIAMS NIH HHS · R01 AR055926 · United States
NIAMS NIH HHS · R01 AR067203 · United States
NIGMS NIH HHS · R01 GM111336 · United States
NIGMS NIH HHS · T32 GM007184 · United States
External Links
PubMed source DOI: 10.1242/dev.153171 PMC Full Text View journal details
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