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PMID: 2884663 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

N-methyl-D-aspartate receptor antagonist desegregates eye-specific stripes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 84 ·No. 12 ·1987-06-00 ·Pages 4342-5

Cline HT, Debski EA, Constantine-Paton M

Abstract

The optic tecta of surgically produced three-eyed tadpoles were chronically exposed to the N-methyl-D-aspartate (NMDA) receptor antagonist aminophosphonovaleric acid (APV), or to NMDA itself, to assess the influence of NMDA receptor/channels on the eye-specific segregation of retinal ganglion cell (RGC) terminals that occurs whenever two retinas innervate one tectal lobe. Exposure of the tectum to the active isomer of APV produces desegregation of the RGC terminals without blocking electrical activity in the afferents or altering their terminal arbor morphology. Exposure to the inactive isomer of APV causes no perturbation of the normal stripe pattern. APV-induced desegregation is completely reversible within 2 weeks of removal of the APV. In addition, exposure of the optic tectum to NMDA results in stripes with sharper borders and fewer forks and fusions than untreated animals. These results suggest that the NMDA receptor/channel plays a role in eye-specific segregation in the three-eyed tadpole.

MeSH Terms
2-Amino-5-phosphonovalerate Afferent Pathways/anatomy & histology,drug effects,physiology Animals Aspartic Acid/analogs & derivatives,pharmacology Evoked Potentials, Visual/drug effects N-Methylaspartate Rana pipiens Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter/physiology Superior Colliculi/drug effects,physiology Valine/analogs & derivatives,pharmacology
Chemicals
Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter Aspartic Acid N-Methylaspartate 2-Amino-5-phosphonovalerate Valine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Cline H T
Debski E A
Constantine-Paton M
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37 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.84.12.4342
Published
1987-06-00
Pages
4342-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC305081
Subset
IM
Grants
NEI NIH HHS · EY05818 · United States
NEI NIH HHS · EY05829 · United States
NEI NIH HHS · EY06039 · United States
External Links
PubMed source DOI: 10.1073/pnas.84.12.4342 PMC Full Text View journal details
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