Stimulation of expression of the human endogenous retrovirus genome by female steroid hormones in human breast cancer cell line T47D.

Journal of virology ·Vol. 61 ·No. 6 ·1987-06-00 ·Pages 2059-62

Ono M, Kawakami M, Ushikubo H

Abstract

Expression of the human endogenous retrovirus genome HERV-K, homologous to mouse mammary tumor virus, was investigated in cultured human tumor cells. In several cell lines, the HERV-K genome was expressed as an 8.8-kilobase poly(A)+ RNA which appeared to be a full-size transcript of this genome. In the human breast cancer cell line T47D, stimulation of HERV-K genome expression by progesterone was observed after estradiol treatment.

MeSH Terms

Breast Neoplasms/microbiology,pathology Cell Line Dexamethasone/pharmacology Estradiol/pharmacology Gene Expression Regulation/drug effects Humans Poly A/biosynthesis Progesterone/pharmacology RNA, Messenger/biosynthesis RNA, Neoplasm/biosynthesis RNA, Viral/biosynthesis Retroviridae/genetics,physiology Transcription, Genetic Virus Activation/drug effects

Chemicals

RNA, Messenger RNA, Neoplasm RNA, Viral Poly A Progesterone Estradiol Dexamethasone

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Ono M

Kawakami M

Ushikubo H

References (21)

21 references, click to expand

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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.61.6.2059-2062.1987

Published

1987-06-00

Pages

2059-62

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC254220

Subset

External Links

PubMed source DOI: 10.1128/JVI.61.6.2059-2062.1987 PMC Full Text View journal details

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Stimulation of expression of the human endogenous retrovirus genome by female steroid hormones in human breast cancer cell line T47D.

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