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PMID: 2883112 Published · ppublish English Case Reports Journal Article Research Support, Non-U.S. Gov't

X-linked immunodeficiency with hyperimmunoglobulinemia M appears to be linked to the DXS42 restriction fragment length polymorphism locus.

Human genetics ·Vol. 76 ·No. 1 ·1987-05-00 ·Pages 96-9

Mensink EJ, Thompson A, Sandkuyl LA, Kraakman ME, Schot JD, Espanol T, Schuurman RK

Abstract

The gene involved in X-linked immunodeficiency with hyperimmunoglobulinemia M (XHM) was localized by the use of nine restriction fragment length polymorphic (RFLP) markers covering the entire X chromosome. Multipoint linkage analysis of RFLP data obtained in a three generation XHM pedigree indicates the Xq24-q27 area around the DXS42 RFLP locus as the most likely localization of the XHM locus.

MeSH Terms
Female Genetic Linkage Genetic Markers Hypergammaglobulinemia/genetics Immunoglobulin M Immunologic Deficiency Syndromes/genetics Lod Score Male Pedigree Polymorphism, Genetic Polymorphism, Restriction Fragment Length X Chromosome
Chemicals
Genetic Markers Immunoglobulin M
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Mensink E J
Thompson A
Sandkuyl L A
Kraakman M E
Schot J D
Espanol T
Schuurman R K
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00283057
Published
1987-05-00
Pages
96-9
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00283057 View journal details
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