Home LiteratureArticle Details
PMID: 2879924 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Localisation of Xp21 meiotic exchange points in Duchenne muscular dystrophy families.

Journal of medical genetics ·Vol. 23 ·No. 6 ·1986-12-00 ·Pages 531-7

Bertelson CJ, Bartley JA, Monaco AP, Colletti-Feener C, Fischbeck K, Kunkel LM

Abstract

The inheritance of Duchenne muscular dystrophy in 25 families was studied with 13 X chromosome specific cloned DNA fragments from 10 loci in and surrounding Xp21. When multiple probes were informative, the meiotic exchange points for each meiosis were located in individual families. Neither genetic nor physical evidence indicates an unusually high recombination rate across Xp21 in these 25 families.

MeSH Terms
Chromosome Deletion Chromosome Mapping Female Genetic Linkage Humans Male Meiosis Muscular Dystrophies/genetics Polymorphism, Restriction Fragment Length Recombination, Genetic Syndrome X Chromosome
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Bertelson C J
Bartley J A
Monaco A P
Colletti-Feener C
Fischbeck K
Kunkel L M
References (33)
33 references, click to expand
  1. Construction of a genetic linkage map in man using restriction fragment length polymorphisms.
    Am J Hum Genet. 1980 May;32(3):314-31 PMID: 6247908
  2. Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis.
    Cell. 1984 May;37(1):67-75 PMID: 6373014
  3. A polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7.
    Nature. 1985 Nov 28-Dec 4;318(6044):380-2 PMID: 2999611
  4. A strategy to reveal high-frequency RFLPs along the human X chromosome.
    Am J Hum Genet. 1984 May;36(3):546-64 PMID: 6328976
  5. Toward a complete linkage map of the human X chromosome: regional assignment of 16 cloned single-copy DNA sequences employing a panel of somatic cell hybrids.
    Am J Hum Genet. 1984 Mar;36(2):265-76 PMID: 6324578
  6. Gene for OTC: characterisation and linkage to Duchenne muscular dystrophy.
    Nucleic Acids Res. 1985 Jan 11;13(1):155-65 PMID: 3839070
  7. Localization of cystic fibrosis locus to human chromosome 7cen-q22.
    Nature. 1985 Nov 28-Dec 4;318(6044):384-5 PMID: 2999612
  8. The genetic linkage map of the human X chromosome.
    Science. 1985 Nov 15;230(4727):753-8 PMID: 4059909
  9. "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.
    Anal Biochem. 1984 Feb;137(1):266-7 PMID: 6329026
  10. Molecular Genetics of the Bithorax Complex in Drosophila melanogaster.
    Science. 1983 Jul 1;221(4605):23-9 PMID: 17737996
  11. Segregation analysis of a marker localised Xp21.2-Xp21.3 in Duchenne and Becker muscular dystrophy families.
    Hum Genet. 1985;71(2):103-7 PMID: 2995231
  12. Expression of an X-linked muscular dystrophy in a female due to translocation involving Xp21 and non-random inactivation of the normal X chromosome.
    Hum Genet. 1984;67(1):115-9 PMID: 6745920
  13. Detection of specific sequences among DNA fragments separated by gel electrophoresis.
    J Mol Biol. 1975 Nov 5;98(3):503-17 PMID: 1195397
  14. Gene deletion and restriction fragment length polymorphisms at the human ornithine transcarbamylase locus.
    Nature. 1985 Feb 28-Mar 6;313(6005):815-7 PMID: 2983225
  15. Report of the Committee on the Genetic Constitution of the X and Y Chromosomes.
    Cytogenet Cell Genet. 1985;40(1-4):296-352 PMID: 3864598
  16. Detection of deletions spanning the Duchenne muscular dystrophy locus using a tightly linked DNA segment.
    Nature. 1985 Aug 29-Sep 4;316(6031):842-5 PMID: 2993910
  17. Specific cloning of DNA fragments absent from the DNA of a male patient with an X chromosome deletion.
    Proc Natl Acad Sci U S A. 1985 Jul;82(14):4778-82 PMID: 2991893
  18. Linkage analysis of two cloned DNA sequences flanking the Duchenne muscular dystrophy locus on the short arm of the human X chromosome.
    Nucleic Acids Res. 1983 Apr 25;11(8):2303-12 PMID: 6304647
  19. Minor Xp21 chromosome deletion in a male associated with expression of Duchenne muscular dystrophy, chronic granulomatous disease, retinitis pigmentosa, and McLeod syndrome.
    Am J Hum Genet. 1985 Mar;37(2):250-67 PMID: 4039107
  20. Analysis of deletions in DNA from patients with Becker and Duchenne muscular dystrophy.
    Nature. 1986 Jul 3-9;322(6074):73-7 PMID: 3014348
  21. Duchenne muscular dystrophy: pathogenetic aspects and genetic prevention.
    Hum Genet. 1984;66(1):17-40 PMID: 6365739
  22. The human met oncogene is related to the tyrosine kinase oncogenes.
    Nature. 1985 Nov 28-Dec 4;318(6044):385-8 PMID: 4069211
  23. Inherited interstitial del(Xp) with minimal clinical consequences: with a note on the location of genes controlling phenotypic features.
    Am J Med Genet. 1979;3(1):43-58 PMID: 474618
  24. DNA linkage analysis of X chromosome-linked chronic granulomatous disease.
    Proc Natl Acad Sci U S A. 1986 May;83(10):3398-401 PMID: 3010296
  25. Localization of DNA sequences in region Xp21 of the human X chromosome: search for molecular markers close to the Duchenne muscular dystrophy locus.
    Am J Hum Genet. 1985 Mar;37(2):235-49 PMID: 2984924
  26. Recombination with pERT87 (DXS164) in families with X-linked muscular dystrophy.
    Lancet. 1986 Jul 12;2(8498):104 PMID: 2873362
  27. Assay for nanogram quantities of DNA in cellular homogenates.
    Anal Biochem. 1979 Jan 15;92(2):497-500 PMID: 87138
  28. Mapping DNA sequences in a human X-chromosome deletion which extends across the region of the Duchenne muscular dystrophy mutation.
    Am J Hum Genet. 1985 May;37(3):451-62 PMID: 2988331
  29. Translocation (X;6) in a female with Duchenne muscular dystrophy: implications for the localisation of the DMD locus.
    J Med Genet. 1981 Dec;18(6):442-7 PMID: 7334502
  30. A closely linked genetic marker for cystic fibrosis.
    Nature. 1985 Nov 28-Dec 4;318(6044):382-4 PMID: 3906407
  31. Deletion on the X chromosome detected by direct DNA analysis in one of two unrelated boys with glycerol kinase deficiency, adrenal hypoplasia, and Duchenne muscular dystrophy.
    Lancet. 1986 Mar 15;1(8481):585-7 PMID: 2869305
  32. Isolation of probes detecting restriction fragment length polymorphisms from X chromosome-specific libraries: potential use for diagnosis of Duchenne muscular dystrophy.
    Hum Genet. 1985;70(2):148-56 PMID: 2989153
  33. Cytogenetic heterogeneity of translocations associated with Duchenne muscular dystrophy.
    Clin Genet. 1986 Feb;29(2):108-15 PMID: 3955860
Article Info
Journal
Journal of medical genetics
Abbr.
J Med Genet
ISSN
0022-2593
DOI
10.1136/jmg.23.6.531
Published
1986-12-00
Pages
531-7
Language
English
Region
England
NLM ID
2985087R
PMCID
PMC1049834
Subset
IM
External Links
PubMed source DOI: 10.1136/jmg.23.6.531 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2