Home LiteratureArticle Details
PMID: 286321 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

DNA fragments of the Mus musculus beta globin haplotypes Hbbs and Hbbd.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 76 ·No. 3 ·1979-03-00 ·Pages 1385-9

Weaver S, Haigwood NL, Hutchison CA, Edgell MH

Abstract

Two alternative haplotypes at the complex locus controlling hemoglobin beta chain synthesis in Mus musculus were compared at the DNA level. As expected, Hbbd homozygotes--which as adults synthesize two species of beta chain--have two genes for beta globin. Adult mice homozygous for the Hbbs haplotype make only a single type of beta polypeptide, yet they also have two beta globin genes. Apparently the two Hbbs genes encode identical proteins, or one of the two genes is not detectably expressed. The Hbbs and Hbbd haplotypes are thus more similar at the DNA level than studies of their polypeptide products have indicated.

MeSH Terms
Animals DNA/metabolism DNA Restriction Enzymes Genes Genotype Globins/biosynthesis Haploidy Homozygote Mice Mice, Inbred Strains Nucleic Acid Hybridization
Chemicals
Globins DNA DNA Restriction Enzymes
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Weaver S
Haigwood N L
Hutchison C A
Edgell M H
References (20)
20 references, click to expand
  1. Changes in restricted human cellular DNA fragments containing globin gene sequences in thalassemias and related disorders.
    Proc Natl Acad Sci U S A. 1978 Mar;75(3):1222-6 PMID: 274714
  2. The cloning of mouse globin and surrounding gene sequences in bacteriophage lambda.
    Cold Spring Harb Symp Quant Biol. 1978;42 Pt 2:915-20 PMID: 277326
  3. Intervening sequence of DNA identified in the structural portion of a mouse beta-globin gene.
    Proc Natl Acad Sci U S A. 1978 Feb;75(2):725-9 PMID: 273235
  4. The rabbit beta-globin gene contains a large large insert in the coding sequence.
    Cell. 1977 Dec;12(4):1097-108 PMID: 597859
  5. Cloning and amplification of alpha and beta mouse globin gene sequences synthesised in vitro.
    Gene. 1977 May;1(3-4):229-39 PMID: 338418
  6. A comparison of two cloned mouse beta-globin genes and their surrounding and intervening sequences.
    Cell. 1978 Jun;14(2):237-45 PMID: 566620
  7. Cloning specific segments of the mammalian genome: bacteriophage lambda containing mouse globin and surrounding gene sequences.
    Proc Natl Acad Sci U S A. 1977 Oct;74(10):4406-10 PMID: 270684
  8. High capacity gel preparative electrophoresis for purification of fragments of genomic DNA.
    Anal Biochem. 1978 Jul 1;87(2):397-410 PMID: 686360
  9. X-ray intensifying screens greatly enhance the detection by autoradiography of the radioactive isotopes 32P and 125I.
    Anal Biochem. 1978 May;86(1):184-92 PMID: 655381
  10. Differential control of the synthesis of two hemoglobin beta chains in normal mice.
    Cell. 1977 Dec;12(4):863-71 PMID: 597861
  11. Preparative fractionation of DNA restriction fragments by reversed phase column chromatography.
    Proc Natl Acad Sci U S A. 1976 Sep;73(9):3117-21 PMID: 1067607
  12. Nucleotide sequence of the rightward operator of phage lambda.
    Proc Natl Acad Sci U S A. 1975 Mar;72(3):1184-8 PMID: 1055375
  13. Cleavage of mouse DNA by a restriction enzyme as a clue to the arrangement of genes.
    Cold Spring Harb Symp Quant Biol. 1974;38:383-95 PMID: 4364785
  14. Rodent hemoglobin structure: a comparison of several species of mice.
    Ann N Y Acad Sci. 1974 Nov 29;241(0):416-33 PMID: 4215357
  15. Genetics of mouse hemoglobins.
    Ann N Y Acad Sci. 1974 Nov 29;241(0):25-38 PMID: 4611305
  16. Sequence of amino acids in the chain of single hemoglobins from C57BL, SWR, and NB mice.
    Biochim Biophys Acta. 1973 Mar 23;303(1):52-60 PMID: 4573825
  17. Hemoglobin Beta chain structural variation in mice: evolutionary and functional implications.
    Science. 1972 Nov 24;178(4063):873-4 PMID: 5085986
  18. Strain distribution and linkage relationship of a mouse embryonic hemoglobin variant.
    Biochem Genet. 1976 Apr;14(3-4):373-81 PMID: 962848
  19. Mouse haemoglobin Beta chains. Sequence data on embryonic y chain and genetic linkage of the Y-chain locus to the adult beta-chain locus Hbb.
    Biochem J. 1976 May 1;155(2):231-41 PMID: 938477
  20. Detection of specific sequences among DNA fragments separated by gel electrophoresis.
    J Mol Biol. 1975 Nov 5;98(3):503-17 PMID: 1195397
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.76.3.1385
Published
1979-03-00
Pages
1385-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC383256
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.76.3.1385 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2