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PMID: 2858 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

The uptake and extrusion of monovalent cations by isolated heart mitochondria.

Molecular and cellular biochemistry ·Vol. 10 ·No. 1 ·1976-01-31 ·Pages 41-63

Brierley GP

Abstract

The factors involved in the movement of monovalent cations across the inner membrane of the isolate heart mitochondrion are reviewed. The evidence suggests that the energy-dependent uptake of K+ and Na+ which results in swelling of the matrix is an electrophoretic response to a negative internal potential. There are no clear cut indications that this electrophoretic cation movement is carrier-mediated and possible modes of entry which do not require a carrier are examined. The evidence also suggests that the monovalent cation for proton exchanger (Na+ greater than K+) present in the membrane may participate in the energy-dependent extrusion of accumulated ions. The two processes, electrophoreti c cation uptake (swelling) and exchange-dependent cation extrusion (contraction) may represent a means of controlling the volume of the mitochondrion within the functioning cell. A number of indications point to the possibility that the volume control process may be mediated by the divalent cations Ca+2 and Mg+2. Studies with mercurial reagents also implicate certain membrane thiol groups in the postulated volume control process.

MeSH Terms
Animals Biological Transport Biological Transport, Active Calcium/metabolism Energy Transfer Hydrogen-Ion Concentration Lead/metabolism Magnesium/metabolism Membranes/metabolism Mitochondria Mitochondria, Muscle/metabolism Mitochondrial Swelling Models, Biological Myocardium Oxidative Phosphorylation Potassium/metabolism Quaternary Ammonium Compounds/metabolism Sodium/metabolism Zinc/metabolism
Chemicals
Quaternary Ammonium Compounds Lead Sodium Magnesium Zinc Potassium Calcium
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Brierley G P
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Article Info
Journal
Molecular and cellular biochemistry
Abbr.
Mol Cell Biochem
ISSN
0300-8177
DOI
10.1007/BF01731680
Published
1976-01-31
Pages
41-63
Language
English
Region
Netherlands
NLM ID
0364456
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01731680 View journal details
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