Expression of the c-myb and c-myc genes is regulated independently in differentiating mouse erythroleukemia cells by common processes of premature transcription arrest and increased mRNA turnover.

Molecular and cellular biology ·Vol. 8 ·No. 9 ·1988-09-00 ·Pages 3938-42

Watson RJ

Abstract

The mechanisms that modulate c-myb mRNA levels in mouse erythroleukemia cells induced toward erythroid differentiation were compared with those that act on c-myc. Both genes exhibited regulation at the levels of premature transcription arrest and RNA turnover. However, these common processes allowed temporally distinct control of gene expression.

MeSH Terms

Animals DNA Restriction Enzymes Dimethyl Sulfoxide/pharmacology Gene Expression Regulation/drug effects Kinetics Leukemia, Erythroblastic, Acute/genetics Leukemia, Experimental/genetics Mice Nucleic Acid Hybridization Proto-Oncogenes/drug effects RNA, Messenger/drug effects,genetics Transcription, Genetic/drug effects

Chemicals

RNA, Messenger DNA Restriction Enzymes Dimethyl Sulfoxide

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Watson R J

Imperial Cancer Research Fund Laboratories, St. Bartholomew's Hospital, Bartholomew Close, London, United Kingdom.

References (24)

24 references, click to expand

Transcripts from the cellular homologs of retroviral oncogenes: distribution among chicken tissues.
Mol Cell Biol. 1982 Jun;2(6):617-24 PMID: 14582157
A transcriptional arrest mechanism involved in controlling constitutive levels of mouse c-myb mRNA.
Oncogene. 1988 Mar;2(3):267-72 PMID: 3281094
Differential expression of the amv gene in human hematopoietic cells.
Proc Natl Acad Sci U S A. 1982 Apr;79(7):2194-8 PMID: 6954533
Early decline in c-myb oncogene expression in the differentiation of human myeloblastic leukemia (ML-1) cells induced with 12-O-tetradecanoylphorbol-13-acetate.
Cancer Res. 1984 Feb;44(2):442-6 PMID: 6198073
Transfer of human globin genes to erythroleukemic mouse cells.
EMBO J. 1982;1(1):15-20 PMID: 6325149
Expression of myb, myc and fos proto-oncogenes during the differentiation of a murine myeloid leukaemia.
Nature. 1984 Jul 19-25;310(5974):249-51 PMID: 6205276
Expression of c-myc changes during differentiation of mouse erythroleukaemia cells.
Nature. 1984 Aug 16-22;310(5978):592-4 PMID: 6462247
Expression of a proto-oncogene (proto-myb) in hemopoietic tissues of mice.
Mol Cell Biol. 1984 Jul;4(7):1206-12 PMID: 6504046
Constitutive c-myc oncogene expression blocks mouse erythroleukaemia cell differentiation but not commitment.
Nature. 1986 Apr 24-30;320(6064):760-3 PMID: 3458027
A block to elongation is largely responsible for decreased transcription of c-myc in differentiated HL60 cells.
Nature. 1986 Jun 12-18;321(6071):702-6 PMID: 3520340
Structural organization and nucleotide sequence of mouse c-myb oncogene: activation in ABPL tumors is due to viral integration in an intron which results in the deletion of the 5' coding sequences.
Nucleic Acids Res. 1986 Jul 11;14(13):5309-20 PMID: 3016644
Expression of a transfected human c-myc oncogene inhibits differentiation of a mouse erythroleukaemia cell line.
Nature. 1986 Aug 21-27;322(6081):748-50 PMID: 3528861
Deregulated expression of c-myc by murine erythroleukaemia cells prevents differentiation.
Nature. 1986 Aug 28-Sep 3;322(6082):848-50 PMID: 3528863
Changes in gene expression associated with induced differentiation of erythroleukemia: protooncogenes, globin genes, and cell division.
Proc Natl Acad Sci U S A. 1986 Sep;83(18):6849-53 PMID: 3462732
Regulated expression of the c-myb and c-myc oncogenes during erythroid differentiation.
J Cell Biochem. 1986;32(1):11-21 PMID: 3464612
Two modes of c-myb activation in virus-induced mouse myeloid tumors.
Mol Cell Biol. 1986 Feb;6(2):380-92 PMID: 3023843
Transcriptional arrest within the first exon is a fast control mechanism in c-myc gene expression.
Nucleic Acids Res. 1986 Nov 11;14(21):8331-46 PMID: 3537956
Transcriptional and post-transcriptional regulation of c-myc expression during the differentiation of murine erythroleukemia Friend cells.
Nucleic Acids Res. 1986 Dec 22;14(24):9653-66 PMID: 3468485
Multiple c-myb transcript cap sites are variously utilized in cells of mouse haemopoietic origin.
EMBO J. 1987 Jun;6(6):1643-51 PMID: 3608990
Differential expression of c-myb mRNA in murine B lymphomas by a block to transcription elongation.
Science. 1987 Sep 18;237(4821):1473-6 PMID: 3498214
Transcription of c-myc in human mononuclear cells is regulated by an elongation block.
Oncogene. 1987;2(1):61-5 PMID: 3438086
Two distinct mechanisms of transcriptional control operate on c-myc during differentiation of HL60 cells.
Mol Cell Biol. 1988 Feb;8(2):867-74 PMID: 3162550
Constitutive expression of a c-myb cDNA blocks Friend murine erythroleukemia cell differentiation.
Mol Cell Biol. 1988 Feb;8(2):884-92 PMID: 2832742
Effect of hexamethylene bisacetamide on the commitment to differentiation of murine erythroleukemia cells.
Cancer Res. 1977 Feb;37(2):440-4 PMID: 264411

Article Info

Journal

Molecular and cellular biology

Abbr.

Mol Cell Biol

ISSN

0270-7306

DOI

10.1128/mcb.8.9.3938-3942.1988

Published

1988-09-00

Pages

3938-42

Language

English

Region

United States

NLM ID

8109087

PMCID

PMC365454

Subset

External Links

PubMed source DOI: 10.1128/mcb.8.9.3938-3942.1988 PMC Full Text View journal details

Analysis Services

Expression of the c-myb and c-myc genes is regulated independently in differentiating mouse erythroleukemia cells by common processes of premature transcription arrest and increased mRNA turnover.

Contact

WeChat Official Account