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PMID: 284359 Published · ppublish English Journal Article

Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 76 ·No. 1 ·1979-01-00 ·Pages 425-9

Chesebro B, Wehrly K

Abstract

The dominant C57BL/10 allele of a single autosomal, non-H-2 gene (Rfv-3) was found to be required for recovery from viremia and leukemia induced by Friend virus complex in H-2b/b mice. In H-2a/a mice, the Rfv-3 gene apparently influenced recovery from viremia in the presence of persistent leukemia because these mice lacked the appropriate H-2 genotype for recovery from leukemia. The Rfv-3 gene was distinct from the Fv-2 gene because recovery from viremia was seen in recombinant-inbred mice with the Fv-2s/s genotype. Furthermore, backcross studies indicated that Rfv-3 and Fv-2 were not linked. The Rfv-3 gene may act by influencing the specific anti-FV humoral antibody response.

MeSH Terms
Animals Chromosome Mapping Friend murine leukemia virus Genes Genetic Linkage Leukemia, Erythroblastic, Acute/blood,genetics,microbiology Leukemia, Experimental/blood,genetics,microbiology Mice
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Chesebro B
Wehrly K
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24 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.76.1.425
Published
1979-01-00
Pages
425-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC382952
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.76.1.425 PMC Full Text View journal details
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