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PMID: 197196 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Genetic control of radiation leukemia virus-induced tumorigenesis II. Influence of Srlv-1, a locus not linked to H-2.

The Journal of experimental medicine ·Vol. 146 ·No. 4 ·1977-10-01 ·Pages 1088-95

Meruelo D, Lieberman M, Deak B, McDevitt HO

Abstract

A single locus, tentatively denoted Srlv-1 (susceptibility to radiation leukemia virus [RadLV]-1), confers dominant susceptibility to RadLV-induced leukemogenesis. Srlv-1 is not linked to H-2, and appears to be distinct from Fv-1 and Fv-2. Preliminary data suggest that Srlv-1 affected virus proliferation. A striking feature of this system is that Srlv-1 overrides the protection afforded by the H2D-associated dominant resistance to RadLV-induced neoplasia.

MeSH Terms
Animals Genes Genes, Dominant Genetic Linkage Histocompatibility Antigens Leukemia Virus, Murine Leukemia, Experimental/etiology,genetics Mice
Chemicals
Histocompatibility Antigens
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Meruelo D
Lieberman M
Deak B
McDevitt H O
References (12)
12 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.146.4.1088
Published
1977-10-01
Pages
1088-95
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2180817
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.146.4.1088 PMC Full Text View journal details
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