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PMID: 2841504 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Harvey sarcoma virus genome contains no extensive sequences unrelated to those of other retroviruses except ras.

Journal of virology ·Vol. 62 ·No. 9 ·1988-09-00 ·Pages 3540-3

Manly KF, Anderson GR, Stoler DL

Abstract

The Harvey murine sarcoma virus genome contains two rat-derived sets of genetic information recombined with the Moloney mouse leukemia virus. The rat sequences represent a ras oncogene and a rat VL30 element. The VL30 sequences have several discrete regions of similarity with retroviral sequences which were detected by searching a protein database for similarities with predicted polypeptide sequences from the VL30 regions. On the 5' side, the most similar sequences were those of feline sarcoma viruses; on the 3' side, murine leukemia viruses were the most similar. Some of the regions of similarity could also be detected directly by searching a nucleic acid sequence database with the viral DNA sequences. The most extensive region of similarity was that which corresponded to the endonuclease in the pol gene of a murine leukemia virus. The majority of the rat-derived sequences present in the Harvey sarcoma virus genome can now be attributed exclusively to ras or retrovirus- or retrotransposon-related sequences.

MeSH Terms
Amino Acid Sequence Animals Base Sequence DNA, Viral/genetics Genes, Viral Genes, ras Harvey murine sarcoma virus/genetics Leukemia Virus, Murine/genetics Mice Molecular Sequence Data Rats Retroviridae/genetics Sarcoma Viruses, Murine/genetics Viral Proteins/genetics
Chemicals
DNA, Viral Viral Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Manly K F
Department of Cell and Molecular Biology, Roswell Park Memorial Institute, Buffalo, New York 14263.
Anderson G R
Stoler D L
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.62.9.3540-3543.1988
Published
1988-09-00
Pages
3540-3
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC253486
Subset
IM
Grants
NCRR NIH HHS · 1 U41 RR01685 · United States
Databases
PIR
UNKNOWN
External Links
PubMed source DOI: 10.1128/JVI.62.9.3540-3543.1988 PMC Full Text View journal details
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