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PMID: 283422 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Appearance of beta-endorphin-like immunoreactivity in human ventricular cerebrospinal fluid upon analgesic electrical stimulation.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 75 ·No. 10 ·1978-10-00 ·Pages 5170-2

Akil H, Richardson DE, Barchas JD, Li CH

Abstract

beta-Endorphin-like immunoreactivity in human ventricular cerebrospinal fluid was measured with a specific radioimmunoassay. The subjects were undergoing a surgical procedure for relief of chronic intractable pain. This procedure involved the focal stimulation of a medial thalamic site adjacent to the wall of the third ventricle. Samples were collected before and during the analgesic stimulation. No beta-endorphin-like immunoreactivity could be detected prior to stimulation, suggesting that baseline levels are below 25 fmol/ml of cerebrospinal fluid. Electrical stimulation led to substantial increases (13- to 20-fold) in immunoreactive material in every subject. These results suggest that beta-endorphin-like material can be released into the ventricular system and may contribute to the pain blockade that results from periventricular stimulation.

MeSH Terms
Analgesia Brain/metabolism Electric Stimulation Endorphins/cerebrospinal fluid,immunology Humans Male Radioimmunoassay Thalamus/metabolism
Chemicals
Endorphins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Akil H
Richardson D E
Barchas J D
Li C H
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32 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.75.10.5170
Published
1978-10-00
Pages
5170-2
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC336286
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.75.10.5170 PMC Full Text View journal details
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