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PMID: 28304897 Published · ppublish English Journal Article

The effects of X-rays on the proliferation dynamics of cells in the imaginal wing disc ofDrosophila melanogaster.

Wilhelm Roux's archives of developmental biology ·Vol. 183 ·No. 2 ·1977-06-00 ·Pages 85-100

Haynie JL, Bryant PJ

Abstract

We report on the size distribution of clones marked by mitotic recombination induced by several different doses of X-rays applied to 72 h oldDrosophila larvae. The results indicate that the radiation significantly reduces the number of cells which undergo normal proliferation in the imaginal wing disc. We estimate that 1000 r reduces by 40-60% the number of cells capable of making a normal contribution to the development of the adult wing. Part of this reduction is due to severe curtailment in the proliferative ability of cells which nevertheless remain capable of adult differentiation; this effect is possibly due to radiation-induced aneuploidy. Cytological evidence suggests that immediate cell death also occurs as a result of radiation doses as low as 100 r. The surviving cells are stimulated to undergo additional proliferation in response to the X-ray damage so that the result is the differentiation of a normal wing.

Keywords
Cell death Clonal analysis Drosophila Imaginal discs Mitotic recombination Pattern regulation
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Haynie John L
Department of Developmental and Cell Biology and Center for Pathobiology, University of California, 92717, Irvine, California, USA.
Bryant Peter J
Department of Developmental and Cell Biology and Center for Pathobiology, University of California, 92717, Irvine, California, USA.
References (24)
24 references, click to expand
  1. Wilhelm Roux Arch Entwickl Mech Org. 1936 Mar;134(1):147-165 PMID: 28354858
  2. The cell cycle of an established line of Drosophila melanogaster cells in vitro.
    Experientia. 1970 Sep 26;26(9):1020-1 PMID: 5478612
  3. [Ultrasonic injuries and roentgen effects in Drosophila melanogaster].
    Strahlentherapie. 1951;85(2):233-53 PMID: 14855208
  4. Cell lineage, growth, and determination in the imaginal leg discs of Drosophila melanogaster.
    Dev Biol. 1969 Sep;20(3):263-90 PMID: 5348957
  5. Developmental genetics of Drosophila imaginal discs.
    Annu Rev Genet. 1973;7:381-433 PMID: 4593310
  6. Cellular degeneration in the production of some mutant phenotypes in Drosophila melanogaster.
    Mol Gen Genet. 1969;103(4):363-79 PMID: 4979601
  7. Some effects of x-rays on development in Drosophila.
    J Exp Zool. 1946 Mar;101:261-80 PMID: 21022220
  8. Intercalary regeneration in imaginal wing disk of Drosophila melanogaster.
    Nature. 1976 Feb 26;259(5545):659-62 PMID: 814470
  9. [Effect of X-rays on the development of male genital imaginal disc in Drosophila melanogaster and investigation of recovery by cell-clone analysis].
    Biophysik. 1972;8(2):158-88 PMID: 4623454
  10. Determination and pattern formation in the imaginal discs of Drosophila.
    Curr Top Dev Biol. 1974;8:41-80 PMID: 4596580
  11. Behaviour in aggregates of irradiated imaginal disk cells ofDrosophila.
    Wilhelm Roux Arch Entwickl Mech Org. 1973 Sep;172(3):187-195 PMID: 28305244
  12. Cell autonomous lethals in Drosophila melanogaster.
    Nat New Biol. 1973 Jan 3;241(105):15-6 PMID: 4633409
  13. Frequency of "Cell-Lethals" among Lethals Obtained at Random in the X-Chromosome of Drosophila Melanogaster.
    Proc Natl Acad Sci U S A. 1936 Jun;22(6):350-4 PMID: 16588081
  14. A model for somatic pairing derived from somatic crossing over with third chromosome rearrangements in Drosophila melanogaster.
    Mol Gen Genet. 1972;115(4):302-13 PMID: 4624405
  15. Parameters of the wing imaginal disc development of Drosophila melanogaster.
    Dev Biol. 1971 Jan;24(1):61-87 PMID: 5001010
  16. Pattern formation in imaginal discs of Drosophila melanogaster after irradiation of embryos and young larvae.
    Dev Biol. 1973 Jun;32(2):345-60 PMID: 4208025
  17. Establishment of compartments in the developing leg imaginal discs ofDrosophila melanogaster.
    Wilehm Roux Arch Dev Biol. 1976 Mar;180(1):9-30 PMID: 28304893
  18. Developmental analysis of two wing scalloping mutantsct 6 andBx J ofDrosophila melanogaster.
    Wilehm Roux Arch Dev Biol. 1975 Sep;178(3):233-245 PMID: 28304774
  19. The influence of the quantity and quality of chromosomal material on the size of the cells in drosophila melanogaster.
    Wilhelm Roux Arch Entwickl Mech Org. 1929 Apr;115(3):363-379 PMID: 28353864
  20. Pattern formation in the wing and haltere imaginal discs after irradiation ofDrosophila melanogaster first instar larvae.
    Wilehm Roux Arch Dev Biol. 1975 Mar;178(1):29-50 PMID: 28305065
  21. The ultrastructure of the developing leg ofDrosophila melanogaster.
    Wilhelm Roux Arch Entwickl Mech Org. 1970 Mar;166(1):1-44 PMID: 28304536
  22. Genetic control of wing disc development in Drosophila.
    Ciba Found Symp. 1975;0(29):161-82 PMID: 1039909
  23. Cell lineage relationships in the imaginal wing disc of Drosophila melanogaster.
    Dev Biol. 1970 Jul;22(3):389-411 PMID: 5423309
  24. Determination of blastoderm cells in Drosophila melanogaster.
    Proc Natl Acad Sci U S A. 1971 Sep;68(9):2217-21 PMID: 5002429
Article Info
Journal
Wilhelm Roux's archives of developmental biology
Abbr.
Wilehm Roux Arch Dev Biol
ISSN
0340-0794
DOI
10.1007/BF00848779
Published
1977-06-00
Pages
85-100
Language
English
Region
Germany
NLM ID
7508796
External Links
PubMed source DOI: 10.1007/BF00848779
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