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PMID: 2823079 Published · ppublish English Comparative Study Journal Article

Homology of Saccharomyces cerevisiae ADH4 to an iron-activated alcohol dehydrogenase from Zymomonas mobilis.

Molecular & general genetics : MGG ·Vol. 209 ·No. 2 ·1987-09-00 ·Pages 374-81

Williamson VM, Paquin CE

Abstract

Insertion of the transposable element Ty at the ADH4 locus results in increased levels of a new alcohol dehydrogenase (ADH) activity in Saccharomyces cerevisiae. The DNA sequence of this locus has been determined. It contains a long open reading frame which is not homologous to the other ADH isozymes that have been characterized in S. cerevisiae nor does it show obvious homology to Drosophila ADH. The hypothetical ADH does, however, show strong homology to the sequence of an iron-activated ADH from the bacterium Zymomonas mobilis. Thus ADH4 appears to encode an ADH structural gene which, along with the Zymomonas enzyme, may define a new family of alcohol dehydrogenases.

MeSH Terms
Aeromonas/enzymology,genetics Alcohol Dehydrogenase/genetics Amino Acid Sequence Animals Base Sequence DNA Transposable Elements Enzyme Activation Genes Genes, Bacterial Genes, Fungal Iron/pharmacology Isoenzymes/genetics Molecular Sequence Data Saccharomyces cerevisiae/enzymology,genetics Sequence Homology, Nucleic Acid
Chemicals
DNA Transposable Elements Isoenzymes Iron Alcohol Dehydrogenase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Williamson V M
ARCO Plant Cell Research Institute, Dublin, CA 94568.
Paquin C E
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34 references, click to expand
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Article Info
Journal
Molecular & general genetics : MGG
Abbr.
Mol Gen Genet
ISSN
0026-8925
DOI
10.1007/BF00329668
Published
1987-09-00
Pages
374-81
Language
English
Region
Germany
NLM ID
0125036
Subset
IM
Databases
GENBANK
X05992
External Links
PubMed source DOI: 10.1007/BF00329668
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