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PMID: 2777338 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Genetic and serological heterogeneity of the supertypic HLA-B locus specificities Bw4 and Bw6.

Immunogenetics ·Vol. 30 ·No. 3 ·1989-00-00 ·Pages 200-7

Müller CA, Engler-Blum G, Gekeler V, Steiert I, Weiss E, Schmidt H

Abstract

Gene cloning and sequencing of the HLA-B locus split antigens B38 (B16.1) and B39 (B16.2) allowed localization of their subtypic as well as their public specificities HLA-Bw4 or -Bw6 to the alpha-helical region of the alpha 1 domain flanked by the amino acid positions 74-83. Comparison of their amino acid sequences with those of other HLA-B-locus alleles established HLA-Bw6 to be distinguished by Ser at residue 77 and Asn at residue 80. In contrast, HLA-Bw4 is characterized by at least seven different patterns of amino acid exchanges at positions 77 and 80-83. Reactivity patterns of Bw4- or Bw6-specific monoclonal antibodies reveal two alloantigenic epitopes contributing to the HLA-Bw4 or -Bw6 specificity residing next to the region of highest diversity of the alpha 1 domain.

MeSH Terms
Amino Acid Sequence Base Sequence Cloning, Molecular HLA-B Antigens/genetics,immunology Humans L Cells Major Histocompatibility Complex Molecular Sequence Data Phenotype Sequence Homology, Nucleic Acid Serotyping Transfection
Chemicals
HLA-B Antigens HLA-Bw4 antigen HLA-Bw6 antigen
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Müller C A
Medizinische Universitätsklinik und Poliklinik, Abteilung II, Tübingen, Federal Republic of Germany.
Engler-Blum G
Gekeler V
Steiert I
Weiss E
Schmidt H
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Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/BF02421207
Published
1989-00-00
Pages
200-7
Language
English
Region
United States
NLM ID
0420404
Subset
IM
Databases
GENBANK
M29864, M29865
External Links
PubMed source DOI: 10.1007/BF02421207 View journal details
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