Home LiteratureArticle Details
PMID: 2460344 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Nucleotide sequences of chimpanzee MHC class I alleles: evidence for trans-species mode of evolution.

The EMBO journal ·Vol. 7 ·No. 9 ·1988-09-00 ·Pages 2765-74

Mayer WE, Jonker M, Klein D, Ivanyi P, van Seventer G, Klein J

Abstract

To obtain an insight into the evolutionary origin of the major histocompatibility complex (MHC) class I polymorphism, a cDNA library was prepared from a heterozygous chimpanzee cell line expressing MHC class I molecules crossreacting with allele-specific HLA-A11 antibodies. The library was screened with human class I locus-specific DNA probes, and clones encoding both alleles at the A and B loci have been identified and sequenced. In addition, the sequences of two HLA-A11 subtypes differing by a single nucleotide substitution have been obtained. The comparison of chimpanzee and human sequences revealed a close similarity (up to 98.5%). The chimpanzee A locus alleles showed greatest similarity to the human HLA-A11/A3 family of alleles, one of them being very close to HLA-A11. Similarly, segments of the ChLA-B alleles displayed greatest similarity to certain HLA-B alleles. The calculated evolutionary branch point for the A11-like alleles is 7 x 10(6) to 9 x 10(6) years, whereas the other A locus alleles diverged between 12 x 10(6) and 17 x 10(6) years ago. Since the human and chimpanzee lineages separated 5 x 10(6) to 7 x 10(6) years ago, our data support the notion that during evolution, MHC alleles are transmitted from one species to the next.

MeSH Terms
Alleles Amino Acid Sequence Animals Base Sequence Biological Evolution Blotting, Northern Blotting, Southern Cell Line, Transformed Cloning, Molecular Cross Reactions DNA/genetics DNA Probes Genes, MHC Class I HLA-A Antigens/genetics,immunology HLA-A11 Antigen Histocompatibility Antigens Class I/genetics,immunology Humans Molecular Sequence Data Pan troglodytes Polymorphism, Genetic RNA/genetics
Chemicals
DNA Probes HLA-A Antigens HLA-A11 Antigen Histocompatibility Antigens Class I RNA DNA
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Mayer W E
Max-Planck-Institut für Biologie, Abteilung Immunogenetik, Tübingen, FRG.
Jonker M
Klein D
Ivanyi P
van Seventer G
Klein J
References (62)
62 references, click to expand
  1. Man's place in Hominoidea as inferred from molecular clocks of DNA.
    J Mol Evol. 1987;26(1-2):132-47 PMID: 3125331
  2. Evidence that polymorphism in the murine major histocompatibility complex may be generated by the assortment of subgene sequences.
    Proc Natl Acad Sci U S A. 1985 May;82(9):2890-4 PMID: 2581256
  3. Comparison of the structure of HLA-Bw47 to HLA-B13 and its relationship to 21-hydroxylase deficiency.
    Immunogenetics. 1988;27(4):281-7 PMID: 3257938
  4. Frameshift mutations and the genetic code. This paper is dedicated to Professor Theodosius Dobzhansky on the occasion of his 66th birthday.
    Cold Spring Harb Symp Quant Biol. 1966;31:77-84 PMID: 5237214
  5. On the stochastic model for estimation of mutational distance between homologous proteins.
    J Mol Evol. 1972 Dec 29;2(1):87-90 PMID: 4668865
  6. Ribonucleic acid isolated by cesium chloride centrifugation.
    Biochemistry. 1974 Jun 4;13(12):2633-7 PMID: 4831907
  7. Evidence for two linked loci controlling ther serologically defined leukocyte antigens of chimpanzees (ChL-A).
    Tissue Antigens. 1974;4(4):313-28 PMID: 4137654
  8. Enhanced representation of HL-A antigens on human lymphocytes after mitogenesis induced by phytohemagglutinin or Epstein-Barr virus.
    Proc Natl Acad Sci U S A. 1975 Aug;72(8):3206-9 PMID: 171657
  9. Detection of specific sequences among DNA fragments separated by gel electrophoresis.
    J Mol Biol. 1975 Nov 5;98(3):503-17 PMID: 1195397
  10. DNA sequencing with chain-terminating inhibitors.
    Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 PMID: 271968
  11. Globin mRNA sequences: analysis of base pairing and evolutionary implications.
    Cold Spring Harb Symp Quant Biol. 1978;42 Pt 2:985-1002 PMID: 277330
  12. The major histocompatibility complex of chimpanzees: identification of several new antigens controlled by the A and B loci of ChLa.
    Tissue Antigens. 1978 Jul;12(1):1-18 PMID: 694913
  13. The HLA-AW24 gene: sequence, surroundings and comparison with the HLA-A2 and HLA-A3 genes.
    Immunogenetics. 1985;21(5):479-89 PMID: 2987115
  14. Primary structure of papain-solubilized human histocompatibility antigen HLA-B27.
    Biochemistry. 1985 Mar 26;24(7):1733-41 PMID: 2408663
  15. Molecular cloning and DNA sequence analysis of genes encoding cytotoxic T lymphocyte-defined HLA-A3 subtypes: the E1 subtype.
    J Immunol. 1985 Oct;135(4):2835-41 PMID: 2993417
  16. The complete primary structure of HLA-Bw58.
    J Biol Chem. 1985 Oct 5;260(22):11924-33 PMID: 2995352
  17. Delineation of functional sites in HLA-B27 antigens. Molecular analysis of HLA-B27 variant Wewak I defined by cytolytic T lymphocytes.
    J Immunol. 1985 Nov;135(5):3323-32 PMID: 3930603
  18. Structural analysis of an HLA-B27 functional variant: identification of residues that contribute to the specificity of recognition by cytolytic T lymphocytes.
    Proc Natl Acad Sci U S A. 1985 Nov;82(21):7394-8 PMID: 2414775
  19. Exon shuffling in vivo can generate novel HLA class I molecules.
    EMBO J. 1985 Nov;4(11):2849-54 PMID: 3877632
  20. Polymorphism in mouse and human class I H-2 and HLA genes is not the result of random independent point mutations.
    Immunogenetics. 1985;22(5):453-70 PMID: 3934067
  21. Organization, sequence and expression of the HLA-B27 gene: a molecular approach to analyze HLA and disease associations.
    Immunobiology. 1985 Dec;170(5):367-80 PMID: 3912316
  22. Complete sequence of HLA-B27 cDNA identified through the characterization of structural markers unique to the HLA-A, -B, and -C allelic series.
    Proc Natl Acad Sci U S A. 1986 Mar;83(5):1428-32 PMID: 3485286
  23. DNA sequence of the coding region of the HLA-B44 gene.
    Immunogenetics. 1986;23(6):396-400 PMID: 3459708
  24. An improved biochemical method for the analysis of HLA-class I antigens. Definition of new HLA-class I subtypes.
    Hum Immunol. 1986 Jun;16(2):169-81 PMID: 3087921
  25. Molecular analysis of an HLA-A2 functional variant CLA defined by cytolytic T lymphocytes.
    J Immunol. 1986 Sep 1;137(5):1642-9 PMID: 3489037
  26. Evolution of the major histocompatibility complex.
    Crit Rev Immunol. 1986;6(4):295-386 PMID: 3536303
  27. Molecular analysis of a functional subtype of HLA-B27. A possible evolutionary pathway for HLA-B27 polymorphism.
    J Immunol. 1986 Dec 1;137(11):3557-65 PMID: 3491141
  28. The primary structure of HLA-A32 suggests a region involved in formation of the Bw4/Bw6 epitopes.
    J Immunol. 1986 Dec 1;137(11):3671-4 PMID: 2431040
  29. The molecular clock runs more slowly in man than in apes and monkeys.
    Nature. 1987 Mar 5-11;326(6108):93-6 PMID: 3102974
  30. Nucleotide sequences of immunoglobulin epsilon genes of chimpanzee and orangutan: DNA molecular clock and hominoid evolution.
    Proc Natl Acad Sci U S A. 1987 Feb;84(4):1080-4 PMID: 3103123
  31. DNA sequence of HLA-A11: remarkable homology with HLA-A3 allows identification of residues involved in epitopes recognized by antibodies and T cells.
    Immunogenetics. 1987;25(4):241-50 PMID: 2437024
  32. A transposable epitope of HLA-B7, B40 molecules.
    Immunogenetics. 1987;25(5):323-8 PMID: 2437025
  33. Structural analysis of an HLA-B27 population variant, B27f. Multiple patterns of amino acid changes within a single polypeptide segment generate polymorphism in HLA-B27.
    J Immunol. 1987 Aug 1;139(3):831-6 PMID: 3110285
  34. Fine specificity of HLA-B27 cellular allorecognition. HLA-B27f is a functional variant distinguishable by cytolytic T cell clones.
    J Immunol. 1987 Aug 1;139(3):837-41 PMID: 2439595
  35. Multiple genetic mechanisms have contributed to the generation of the HLA-A2/A28 family of class I MHC molecules.
    J Immunol. 1987 Aug 1;139(3):936-41 PMID: 3496393
  36. DNA sequences of the genes that encode the CTL-defined HLA-A2 variants M7 and DK1.
    Immunogenetics. 1987;26(3):190-2 PMID: 3497874
  37. Origin of major histocompatibility complex polymorphism: the trans-species hypothesis.
    Hum Immunol. 1987 Jul;19(3):155-62 PMID: 3305436
  38. Structure of the human class I histocompatibility antigen, HLA-A2.
    Nature. 1987 Oct 8-14;329(6139):506-12 PMID: 3309677
  39. The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens.
    Nature. 1987 Oct 8-14;329(6139):512-8 PMID: 2443855
  40. An evaluation of the molecular clock hypothesis using mammalian DNA sequences.
    J Mol Evol. 1987;25(4):330-42 PMID: 3118047
  41. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.
    Biochemistry. 1979 Nov 27;18(24):5294-9 PMID: 518835
  42. Sequencing end-labeled DNA with base-specific chemical cleavages.
    Methods Enzymol. 1980;65(1):499-560 PMID: 6246368
  43. The evolution of genes: the chicken preproinsulin gene.
    Cell. 1980 Jun;20(2):555-66 PMID: 7388949
  44. A subcloning strategy for DNA sequence analysis.
    Nucleic Acids Res. 1980 Dec 11;8(23):5541-9 PMID: 6258146
  45. Nucleotide sequence divergence and functional constraint in mRNA evolution.
    Proc Natl Acad Sci U S A. 1980 Dec;77(12):7328-32 PMID: 6938980
  46. Comparison of nucleotide sequences of mRNAs belonging to the mouse H-2 multigene family.
    Nucleic Acids Res. 1982 Feb 11;10(3):1039-49 PMID: 6278432
  47. Structure of crossreactive human histocompatibility antigens HLA-A28 and HLA-A2: possible implications for the generation of HLA polymorphism.
    Proc Natl Acad Sci U S A. 1982 Jun;79(12):3813-7 PMID: 6179086
  48. Comparative structural analysis of HLA-A2 antigens distinguishable by cytotoxic T lymphocytes: variants M7 and DR1.
    Biochemistry. 1982 Nov 23;21(24):6313-21 PMID: 6983890
  49. The structure of a mutant H-2 gene suggests that the generation of polymorphism in H-2 genes may occur by gene conversion-like events.
    Nature. 1983 Feb 24;301(5902):671-4 PMID: 6828150
  50. Comparative structural analysis of HLA-A2 antigens distinguishable by cytotoxic T lymphocytes. II. Variant DK1: evidence for a discrete CTL recognition region.
    J Immunol. 1983 Apr;130(4):1856-62 PMID: 6601143
  51. Unusual evolutionary conservation and frequent DNA segment exchange in class I genes of the major histocompatibility complex.
    Proc Natl Acad Sci U S A. 1983 May;80(9):2671-5 PMID: 6573677
  52. Sequences of human repetitive DNA, non-alpha-globin genes, and major histocompatibility locus genes.
    Cold Spring Harb Symp Quant Biol. 1983;47 Pt 2:1079-86 PMID: 6574860
  53. Primary structure of papain-solubilized human histocompatibility antigen HLA-B40 (-Bw60). An outline of alloantigenic determinants.
    Biochemistry. 1983 Aug 2;22(16):3961-9 PMID: 6193808
  54. Genes of the major histocompatibility complex in mouse and man.
    Science. 1983 Nov 18;222(4625):727-33 PMID: 6356354
  55. A simple and very efficient method for generating cDNA libraries.
    Gene. 1983 Nov;25(2-3):263-9 PMID: 6198242
  56. Complete nucleotide sequence of a functional class I HLA gene, HLA-A3: implications for the evolution of HLA genes.
    EMBO J. 1984 Apr;3(4):887-94 PMID: 6609814
  57. "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.
    Anal Biochem. 1984 Feb;137(1):266-7 PMID: 6329026
  58. Isolation of HLA locus-specific DNA probes from the 3'-untranslated region.
    Proc Natl Acad Sci U S A. 1984 Aug;81(16):5175-8 PMID: 6591185
  59. Cloning and complete sequence of an HLA-A2 gene: analysis of two HLA-A alleles at the nucleotide level.
    J Immunol. 1985 Apr;134(4):2727-33 PMID: 2982951
  60. Transcription termination and 3' processing: the end is in site!
    Cell. 1985 Jun;41(2):349-59 PMID: 2580642
  61. Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors.
    Gene. 1985;33(1):103-19 PMID: 2985470
  62. DNA hybridization evidence of hominoid phylogeny: results from an expanded data set.
    J Mol Evol. 1987;26(1-2):99-121 PMID: 3125341
Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1988-09-00
Pages
2765-74
Language
English
Region
England
NLM ID
8208664
PMCID
PMC457067
Subset
IM
Grants
NIAID NIH HHS · AI23667 · United States
Databases
GENBANK
X12781, X13111, X13112, X13113, X13114, X13115, X13116
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2