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PMID: 2767197 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Two classes of cortical GABA neurons defined by differential calcium binding protein immunoreactivities.

Experimental brain research ·Vol. 76 ·No. 2 ·1989-00-00 ·Pages 467-72

Hendry SH, Jones EG, Emson PC, Lawson DE, Heizmann CW, Streit P

Abstract

Calcium ions play a key role in many aspects of neuronal behavior and certain calcium binding proteins that may influence this behavior are differentially distributed in the central nervous system. In this study it is shown that immunoreactivity for calbindin-28 and for parvalbumin is localized in separate populations of inhibitory GABA interneurons in all areas of the neocortex of Old World monkeys. Virtually all GABA neurons show immunoreactivity for one or other calcium binding protein but, except for a few cells in layer IV, GABA cells do not show immunoreactivity for both proteins. Among the two cell populations, parvalbumin immunoreactivity characterizes basket neurons while calbindin immunoreactivity characterizes double bouquet neurons. These findings suggest that the two GABA cell types differ in their regulation of calcium homeostasis and may yield clues to their different roles in intracortical circuitry.

MeSH Terms
Animals Calbindins Calcium-Binding Proteins/metabolism Cerebral Cortex/cytology,metabolism Immunohistochemistry Interneurons/classification,metabolism Macaca fascicularis Muscle Proteins/metabolism Parvalbumins/metabolism S100 Calcium Binding Protein G/metabolism gamma-Aminobutyric Acid/metabolism
Chemicals
Calbindins Calcium-Binding Proteins Muscle Proteins Parvalbumins S100 Calcium Binding Protein G gamma-Aminobutyric Acid
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Hendry S H
Department of Anatomy and Neurobiology, University of California, Irvine 92717.
Jones E G
Emson P C
Lawson D E
Heizmann C W
Streit P
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Article Info
Journal
Experimental brain research
Abbr.
Exp Brain Res
ISSN
0014-4819
DOI
10.1007/BF00247904
Published
1989-00-00
Pages
467-72
Language
English
Region
Germany
NLM ID
0043312
Subset
IM
Grants
NEI NIH HHS · EY06432 · United States
NEI NIH HHS · EY07193 · United States
NINDS NIH HHS · NS21377 · United States
External Links
PubMed source DOI: 10.1007/BF00247904 View journal details
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