Structure and evolution of calcium-modulated proteins.

CRC critical reviews in biochemistry ·Vol. 8 ·No. 2 ·1980-00-00 ·Pages 119-74

Kretsinger RH

Abstract

This review suggests that the intracellular functions of calcium are best understood in terms of calcium's functioning as a second messenger. Further, when functioning as a second messenger, calcium completes its mission not by transferring charge nor by binding to lipid but by binding to specific targets, calcium-modulated proteins. This concept is broadly interpreted to include proteins involved in calcium transport. There is strong evidence that many, if not all, of these calcium-modulated proteins are homologs. Their structures and properties are contrasted to those of extracellular calcium-binding proteins which are not homologous to one another or to the intracellular calcium-modulated proteins. Finally, this line of thought leads to a suggestion of the evolutionary reason for the choice of calcium as the sole inorganic second messenger.

MeSH Terms

3',5'-Cyclic-AMP Phosphodiesterases/metabolism Adenine Nucleotides/metabolism Adenylyl Cyclases/metabolism Aequorin/metabolism Amino Acid Sequence Animals Annexin A7 Biological Evolution Calcium-Binding Proteins/physiology Calcium-Transporting ATPases/metabolism Calmodulin/physiology Contractile Proteins/metabolism Diphosphates/metabolism Firefly Luciferin/pharmacology Humans Intestinal Mucosa/metabolism Invertebrates/metabolism Magnesium/pharmacology Myosins/metabolism Parvalbumins/metabolism Peptide Hydrolases/metabolism Phosphorylase Kinase/metabolism Phosphorylation Protein Binding Protein Conformation Proteins/metabolism Protozoan Proteins Sarcoplasmic Reticulum/enzymology Substrate Specificity Troponin/metabolism Tubulin/metabolism Tyrosine 3-Monooxygenase/metabolism

Chemicals

Adenine Nucleotides Annexin A7 Calcium-Binding Proteins Calmodulin Contractile Proteins Diphosphates Parvalbumins Proteins Protozoan Proteins Troponin Tubulin spasmin Aequorin Firefly Luciferin Tyrosine 3-Monooxygenase Phosphorylase Kinase 3',5'-Cyclic-AMP Phosphodiesterases Peptide Hydrolases Myosins Adenylyl Cyclases Calcium-Transporting ATPases Magnesium

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Kretsinger R H

Article Info

Journal

CRC critical reviews in biochemistry

Abbr.

CRC Crit Rev Biochem

ISSN

0045-6411

DOI

10.3109/10409238009105467

Published

1980-00-00

Pages

119-74

Language

English

Region

United States

NLM ID

0330403

Subset

External Links

PubMed source DOI: 10.3109/10409238009105467

Analysis Services

Structure and evolution of calcium-modulated proteins.

Contact

WeChat Official Account