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PMID: 2760977 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Interactions of minute virus of mice and adenovirus with host nucleoli.

Journal of virology ·Vol. 63 ·No. 9 ·1989-09-00 ·Pages 3651-60

Walton TH, Moen PT, Fox E, Bodnar JW

Abstract

Biochemical evidence is presented that both minute virus of mice (MVM) and adenovirus interact with the nucleolus during lytic growth and that MVM can also target specific changes involving nucleolar components in adenovirus-infected cells. These virus-nucleolus interactions were studied by analysis of intranuclear compartmentalization of both viral DNAs and host nucleolar proteins: (i) MVM in mouse cells (its normal host) replicates its DNA in the host nucleoli; (ii) specific nucleolar proteins as well as small nuclear ribonucleoprotein antigens are recompartmentalized to multiple intranuclear foci in adenovirus-infected HeLa cells; and (iii) when adenovirus helps MVM DNA replication in a nonpermissive human cell (HeLa), the MVM DNA is also recompartmentalized for synthesis. The data suggest mechanisms for disruption of nucleolar function common to oncogenic or oncolytic virus lytic growth and cell transformation.

MeSH Terms
Adenoviridae/physiology Animals Autoantigens/analysis Cell Nucleolus/analysis,microbiology,physiology DNA Replication DNA, Viral/analysis HeLa Cells Helper Viruses/physiology Humans Mice Minute Virus of Mice/physiology Parvoviridae/physiology Viral Proteins/analysis Virus Replication snRNP Core Proteins
Chemicals
Autoantigens DNA, Viral Viral Proteins snRNP Core Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Walton T H
Department of Biology, Northeastern University, Boston, Massachusetts 02115.
Moen P T
Fox E
Bodnar J W
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.63.9.3651-3660.1989
Published
1989-09-00
Pages
3651-60
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC250955
Subset
IM
Grants
NIGMS NIH HHS · GM-35238 · United States
External Links
PubMed source DOI: 10.1128/JVI.63.9.3651-3660.1989 PMC Full Text View journal details
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