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PMID: 27383980 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Diet-microbiota interactions as moderators of human metabolism.

Nature ·Vol. 535 ·No. 7610 ·2016-00-07 ·Pages 56-64

Sonnenburg JL, Bäckhed F

Abstract

It is widely accepted that obesity and associated metabolic diseases, including type 2 diabetes, are intimately linked to diet. However, the gut microbiota has also become a focus for research at the intersection of diet and metabolic health. Mechanisms that link the gut microbiota with obesity are coming to light through a powerful combination of translation-focused animal models and studies in humans. A body of knowledge is accumulating that points to the gut microbiota as a mediator of dietary impact on the host metabolic status. Efforts are focusing on the establishment of causal relationships in people and the prospect of therapeutic interventions such as personalized nutrition.

MeSH Terms
Animals Diabetes Mellitus, Type 2/diet therapy,metabolism,microbiology Diet Fatty Acids/metabolism Gastrointestinal Microbiome/physiology Humans Inflammation/diet therapy,metabolism,microbiology Metabolic Diseases/diet therapy,metabolism,microbiology Metabolism Obesity/diet therapy,metabolism,microbiology Precision Medicine/methods Signal Transduction
Chemicals
Fatty Acids
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sonnenburg Justin L
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA.
Bäckhed Fredrik
Wallenberg Laboratory for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden. | Section for Metabolic Receptology, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
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Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
DOI
10.1038/nature18846
Published
2016-00-07
Pages
56-64
Language
English
Region
England
NLM ID
0410462
PMCID
PMC5991619
Subset
IM
Grants
European Research Council · 615362 · International
NIDDK NIH HHS · R01 DK085025 · United States
NIDDK NIH HHS · R01-DK085025 · United States
External Links
PubMed source DOI: 10.1038/nature18846 PMC Full Text View journal details
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