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PMID: 26951663 Published · ppublish English Journal Article

Use of the Fluidigm C1 platform for RNA sequencing of single mouse pancreatic islet cells.

Xin Y, Kim J, Ni M, Wei Y, Okamoto H, Lee J, Adler C, Cavino K, Murphy AJ, Yancopoulos GD, Lin HC, Gromada J

Abstract

This study provides an assessment of the Fluidigm C1 platform for RNA sequencing of single mouse pancreatic islet cells. The system combines microfluidic technology and nanoliter-scale reactions. We sequenced 622 cells, allowing identification of 341 islet cells with high-quality gene expression profiles. The cells clustered into populations of α-cells (5%), β-cells (92%), δ-cells (1%), and pancreatic polypeptide cells (2%). We identified cell-type-specific transcription factors and pathways primarily involved in nutrient sensing and oxidation and cell signaling. Unexpectedly, 281 cells had to be removed from the analysis due to low viability, low sequencing quality, or contamination resulting in the detection of more than one islet hormone. Collectively, we provide a resource for identification of high-quality gene expression datasets to help expand insights into genes and pathways characterizing islet cell types. We reveal limitations in the C1 Fluidigm cell capture process resulting in contaminated cells with altered gene expression patterns. This calls for caution when interpreting single-cell transcriptomics data using the C1 Fluidigm system.

Keywords
Fluidigm C1 glucagon insulin pancreatic islet cells single-cell RNA sequencing
MeSH Terms
Animals Islets of Langerhans/cytology,metabolism Mice Mice, Inbred C57BL Sequence Analysis, RNA/methods Transcription Factors/metabolism
Chemicals
Transcription Factors
Authors & Affiliations
12 authors, click to expand affiliations / ORCID
Xin Yurong
Regeneron Pharmaceuticals, Tarrytown, NY 10591.
Kim Jinrang
Regeneron Pharmaceuticals, Tarrytown, NY 10591.
Ni Min
Regeneron Pharmaceuticals, Tarrytown, NY 10591.
Wei Yi
Regeneron Pharmaceuticals, Tarrytown, NY 10591.
Okamoto Haruka
Regeneron Pharmaceuticals, Tarrytown, NY 10591.
Lee Joseph
Regeneron Pharmaceuticals, Tarrytown, NY 10591.
Adler Christina
Regeneron Pharmaceuticals, Tarrytown, NY 10591.
Cavino Katie
Regeneron Pharmaceuticals, Tarrytown, NY 10591.
Murphy Andrew J
Regeneron Pharmaceuticals, Tarrytown, NY 10591.
Yancopoulos George D
Regeneron Pharmaceuticals, Tarrytown, NY 10591 george@regeneron.com Jesper.Gromada@regeneron.com.
Lin Hsin Chieh
Regeneron Pharmaceuticals, Tarrytown, NY 10591.
Gromada Jesper
Regeneron Pharmaceuticals, Tarrytown, NY 10591 george@regeneron.com Jesper.Gromada@regeneron.com.
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
1091-6490
Published
2016-03-22
Epub
2016-00-07
Pages
3293-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC4812709
Subset
IM
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