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PMID: 22424227 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Diabetes mellitus and the β cell: the last ten years.

Cell ·Vol. 148 ·No. 6 ·2012-03-16 ·Pages 1160-71

Ashcroft FM, Rorsman P

Abstract

Diabetes is a major global problem. During the past decade, the genetic basis of various monogenic forms of the disease, and their underlying molecular mechanisms, have been elucidated. Many genes that increase type 2 diabetes (T2DM) risk have also been identified, but how they do so remains enigmatic. Nevertheless, defective insulin secretion emerges as the main culprit in both monogenic and polygenic diabetes, with environmental and lifestyle factors, via obesity, accounting for the current dramatic increase in T2DM. There also have been significant advances in therapy, particularly for some monogenic disorders. We review here what ails the β cell and how its function may be restored.

MeSH Terms
Animals Diabetes Mellitus/genetics,metabolism Diabetes Mellitus, Type 2/drug therapy,genetics,pathology Diet Humans Insulin-Secreting Cells/cytology,metabolism,pathology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ashcroft Frances M
Department of Physiology, Anatomy, and Genetics, Henry Wellcome Centre for Gene Function, University of Oxford, Sherrington Building, Parks Road, Oxford OX1 3PT, UK. frances.ashcroft@dpag.ox.ac.uk
Rorsman Patrik
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Article Info
Journal
Cell
Abbr.
Cell
ISSN
1097-4172
DOI
10.1016/j.cell.2012.02.010
Email
frances.ashcroft@dpag.ox.ac.uk
Published
2012-03-16
Pages
1160-71
Language
English
Region
United States
NLM ID
0413066
PMCID
PMC5890906
Subset
IM
Grants
Wellcome Trust · United Kingdom
Wellcome Trust · 084655 · United Kingdom
Wellcome Trust · 095531 · United Kingdom
Medical Research Council · G0801995 · United Kingdom
External Links
PubMed source DOI: 10.1016/j.cell.2012.02.010 PMC Full Text View journal details
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