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PMID: 2670901 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Regulation of the Escherichia coli glyA gene by the metR gene product and homocysteine.

Journal of bacteriology ·Vol. 171 ·No. 9 ·1989-09-00 ·Pages 4958-62

Plamann MD, Stauffer GV

Abstract

The methionine component of glyA gene regulation in Escherichia coli K-12 was investigated. The results indicate that the glyA gene is positively controlled by the metR gene product. Activation of glyA by the MetR protein requires homocysteine, an intermediate in methionine biosynthesis. The positive-acting metR regulatory system functions independently of a regulatory system shown previously to control glyA gene expression.

MeSH Terms
Escherichia coli/drug effects,enzymology,genetics Gene Expression Regulation Genes/drug effects Genes, Bacterial/drug effects Genotype Glycine Hydroxymethyltransferase/biosynthesis,genetics Homocysteine/pharmacology Methionine Mutation Salmonella typhimurium/genetics Transferases/genetics
Chemicals
Homocysteine Methionine Transferases Glycine Hydroxymethyltransferase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Plamann M D
Department of Microbiology, University of Iowa, Iowa City 52242.
Stauffer G V
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20 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.171.9.4958-4962.1989
Published
1989-09-00
Pages
4958-62
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC210303
Subset
IM
Grants
NIGMS NIH HHS · GM-26878 · United States
External Links
PubMed source DOI: 10.1128/jb.171.9.4958-4962.1989 PMC Full Text View journal details
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