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PMID: 2668731 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Rapid induction of polyadenylated H1 histone mRNAs in mouse erythroleukemia cells is regulated by c-myc.

Molecular and cellular biology ·Vol. 9 ·No. 6 ·1989-06-00 ·Pages 2332-40

Cheng GH, Skoultchi AI

Abstract

Chemically induced differentiation of murine erythroleukemia cells is a multistep process involving a precommitment period in which exposure to inducer leads to cells that are irreversibly committed to terminal differentiation. Certain changes in the expression of cellular proto-oncogenes are an important feature of the precommitment phase. We have identified two H1 histone genes that are rapidly induced during this period. Unlike most histone genes, these two H1 genes encode polyadenylated mRNAs with long 3' untranslated regions. To investigate the relationship between induction of the H1 mRNAs and changes in proto-oncogene expression, we studied two independent series of mouse erythroleukemia cell lines that are inhibited from differentiating because of deregulated expression of transfected copies of c-myc or c-myb. The results showed that induction of the H1 mRNAs was negatively regulated by c-myc. The two H1 histone genes are among the first examples of specific cellular genes that are regulated by c-myc. The timing of their induction suggests that they may play an important role in achieving commitment to terminal differentiation.

MeSH Terms
Acetamides Animals Cell Differentiation Gene Expression Regulation Histones/genetics Mice Models, Biological Poly A/genetics Proto-Oncogene Proteins/genetics Proto-Oncogene Proteins c-myb Proto-Oncogene Proteins c-myc Proto-Oncogenes RNA, Messenger/biosynthesis,genetics Tumor Cells, Cultured
Chemicals
Acetamides Histones Proto-Oncogene Proteins Proto-Oncogene Proteins c-myb Proto-Oncogene Proteins c-myc RNA, Messenger Poly A hexamethylene bisacetamide
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cheng G H
Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461.
Skoultchi A I
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.9.6.2332-2340.1989
Published
1989-06-00
Pages
2332-40
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC362306
Subset
IM
Grants
NCI NIH HHS · CA 13330 · United States
NCI NIH HHS · CA16368 · United States
External Links
PubMed source DOI: 10.1128/mcb.9.6.2332-2340.1989 PMC Full Text View journal details
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