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PMID: 26556351 Published · epublish English Journal Article Research Support, Non-U.S. Gov't Review

Endoplasmic Reticulum Stress Signaling in Plant Immunity--At the Crossroad of Life and Death.

International journal of molecular sciences ·Vol. 16 ·No. 11 ·2015-11-05 ·Pages 26582-98

Kørner CJ, Du X, Vollmer ME, Pajerowska-Mukhtar KM

Abstract

Rapid and complex immune responses are induced in plants upon pathogen recognition. One form of plant defense response is a programmed burst in transcription and translation of pathogenesis-related proteins, of which many rely on ER processing. Interestingly, several ER stress marker genes are up-regulated during early stages of immune responses, suggesting that enhanced ER capacity is needed for immunity. Eukaryotic cells respond to ER stress through conserved signaling networks initiated by specific ER stress sensors tethered to the ER membrane. Depending on the nature of ER stress the cell prioritizes either survival or initiates programmed cell death (PCD). At present two plant ER stress sensors, bZIP28 and IRE1, have been described. Both sensor proteins are involved in ER stress-induced signaling, but only IRE1 has been additionally linked to immunity. A second branch of immune responses relies on PCD. In mammals, ER stress sensors are involved in activation of PCD, but it is unclear if plant ER stress sensors play a role in PCD. Nevertheless, some ER resident proteins have been linked to pathogen-induced cell death in plants. In this review, we will discuss the current understanding of plant ER stress signaling and its cross-talk with immune signaling.

Keywords
Arabidopsis ER stress signaling IRE1 plant immune responses programmed cell death
MeSH Terms
Animals Apoptosis Endoplasmic Reticulum Stress Host-Pathogen Interactions Plant Immunity Plant Physiological Phenomena Signal Transduction
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Kørner Camilla J
Department of Biology, University of Alabama at Birmingham, 1300 University Blvd., Birmingham, AL 35294, USA. ckoerner@uab.edu.
Du Xinran
Department of Biology, University of Alabama at Birmingham, 1300 University Blvd., Birmingham, AL 35294, USA. xinrandu@uab.edu.
Vollmer Marie E
Department of Biology, University of Alabama at Birmingham, 1300 University Blvd., Birmingham, AL 35294, USA. mvollmer@uab.edu.
Pajerowska-Mukhtar Karolina M
Department of Biology, University of Alabama at Birmingham, 1300 University Blvd., Birmingham, AL 35294, USA. kmukhtar@uab.edu.
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Article Info
Journal
International journal of molecular sciences
Abbr.
Int J Mol Sci
ISSN
1422-0067
DOI
10.3390/ijms161125964
Email
ckoerner@uab.edu
xinrandu@uab.edu
mvollmer@uab.edu
kmukhtar@uab.edu
Published
2015-11-05
Epub
2015-00-05
Pages
26582-98
Language
English
Region
Switzerland
NLM ID
101092791
PMCID
PMC4661823
Subset
IM
External Links
PubMed source DOI: 10.3390/ijms161125964 PMC Full Text View journal details
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