Characterization of receptors mediating 5-hydroxytryptamine- and catecholamine-induced platelet aggregation, assessed by the actions of alpha- and beta-blockers, butyrophenones, 5-HT antagonists and chlorpromazine.

British journal of pharmacology ·Vol. 62 ·No. 4 ·1978-04-00 ·Pages 537-42

Boullin DJ, Glenton PA

Abstract

1 Blood platelets from normal human volunteers were isolated and aggregated in vitro with 5-hydroxytryptamine (5-HT), noradrenaline (NA), dopamine and N-dimethyldopamine (DMDA). 2 The effects of 5-HT antagonists, alpha- and beta-adrenoceptor blocking agents, butyrophenones and chlorpromazine upon aggregation induced by the four amines were investigated. 3 Only the the 5-HT antagonists, chlorpromazine and spiroperidol were potent inhibitors of 5-HT-induced aggregation, and only phentolamine was a potent inhibitor of the catecholamine-induced aggregation. 4 Evidence was obtained for two populations of receptors, one for 5-HT and one for the three catecholamines.

MeSH Terms

Adrenergic alpha-Antagonists/pharmacology Adrenergic beta-Antagonists/pharmacology Butyrophenones/pharmacology Catecholamines/pharmacology Chlorpromazine/pharmacology Dopamine/analogs & derivatives,pharmacology Humans In Vitro Techniques Norepinephrine/pharmacology Platelet Aggregation/drug effects Receptors, Adrenergic/drug effects Receptors, Serotonin/drug effects Serotonin Antagonists/pharmacology

Chemicals

Adrenergic alpha-Antagonists Adrenergic beta-Antagonists Butyrophenones Catecholamines Receptors, Adrenergic Receptors, Serotonin Serotonin Antagonists Chlorpromazine Dopamine Norepinephrine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Boullin D J

Glenton P A

References (15)

15 references, click to expand

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Article Info

Journal

British journal of pharmacology

Abbr.

Br J Pharmacol

ISSN

0007-1188

DOI

10.1111/j.1476-5381.1978.tb07758.x

Published

1978-04-00

Pages

537-42

Language

English

Region

England

NLM ID

7502536

PMCID

PMC1668039

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1978.tb07758.x PMC Full Text View journal details

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Characterization of receptors mediating 5-hydroxytryptamine- and catecholamine-induced platelet aggregation, assessed by the actions of alpha- and beta-blockers, butyrophenones, 5-HT antagonists and chlorpromazine.

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