Inhibitory effect of chlorpromazine on the syndrome of hyperactivity produced by L-tryptophan or 5-methoxy-N,N-dimethyltryptamine in rats treated with a monoamine oxidase inhibitor.

British journal of pharmacology ·Vol. 43 ·No. 4 ·1971-12-00 ·Pages 856-64

Grahame-Smith DG

Abstract

1. The hyperactivity and hyperpyrexia produced by L-tryptophan in rats treated with a monoamine oxidase inhibitor was inhibited by chlorpromazine.2. Chlorpromazine did not inhibit the increased rate of synthesis of brain 5-hydroxytryptamine (5-HT) produced by tryptophan loading.3. Hyperactivity and hyperpyrexia were also produced by 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) in rats. Pretreatment with a monoamine oxidase inhibitor potentiated the hyperactivity response. Pretreatment of rats with p-chlorophenylalanine did not inhibit hyperactivity produced by 5-MeODMT.4. Chlorpromazine inhibits hyperactivity caused by tryptophan or 5-MeODMT after monoamine oxidase inhibition either by competition with 5-HT or 5-MeODMT, respectively, at receptor sites or by physiological antagonism.

MeSH Terms

Animals Brain/drug effects,metabolism Chlorpromazine/pharmacology Drug Synergism Fenclonine/pharmacology Fever/chemically induced Humans Hyperkinesis/chemically induced Male Monoamine Oxidase Inhibitors/pharmacology Rats Receptors, Drug Serotonin/biosynthesis Tryptamines/antagonists & inhibitors,pharmacology Tryptophan/antagonists & inhibitors,pharmacology

Chemicals

Monoamine Oxidase Inhibitors Receptors, Drug Tryptamines Serotonin Tryptophan Fenclonine Chlorpromazine

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Grahame-Smith D G

References (11)

11 references, click to expand

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Article Info

Journal

British journal of pharmacology

Abbr.

Br J Pharmacol

ISSN

0007-1188

DOI

10.1111/j.1476-5381.1971.tb07222.x

Published

1971-12-00

Pages

856-64

Language

English

Region

England

NLM ID

7502536

PMCID

PMC1665725

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1971.tb07222.x PMC Full Text View journal details

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Inhibitory effect of chlorpromazine on the syndrome of hyperactivity produced by L-tryptophan or 5-methoxy-N,N-dimethyltryptamine in rats treated with a monoamine oxidase inhibitor.

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