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PMID: 25895127 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Ubiquitin E3 ligase MARCH7 promotes ovarian tumor growth.

Oncotarget ·Vol. 6 ·No. 14 ·2015-05-20 ·Pages 12174-87

Hu J, Meng Y, Yu T, Hu L, Mao M

Abstract

Ubiquitin E3 ligase MARCH7 is involved in T cell proliferation and neuronal development. We found that expression of MARCH7 was higher in ovarian cancer tissues than normal ovarian tissues. Silencing MARCH7 decreased cell proliferation, migration, and invasion. Ectopic expression of MARCH7 increased cell proliferation, migration and invasion. Silencing MARCH7 prevented ovarian cancer growth in mice. Silencing MARCH7 inhibited NFkB and Wnt/β-catenin pathway. In agreement, ectopically expressed MARCH7 activated NFkB and Wnt/β-catenin pathways. Finally, MARCH7 was regulated by miR-101. Thus, MARCH7 is oncogenic and a potential target (oncotarget) for ovarian cancer therapy.

Keywords
MARCH7 NF-Kb Wnt ovarian cancer β-catenin
MeSH Terms
Animals Cell Line, Tumor Cell Proliferation Female Humans Mice Ovarian Neoplasms/genetics,pathology RNA, Messenger/metabolism Ubiquitin-Protein Ligases/genetics,metabolism
Chemicals
RNA, Messenger Ubiquitin-Protein Ligases
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Hu Jianguo
Department of Obstetrics and Gynecology, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Meng Ying
Department of Obstetrics and Gynecology, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Yu Tinghe
Department of Obstetrics and Gynecology, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Hu Lina
Department of Obstetrics and Gynecology, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Mao Ming
Department of Obstetrics and Gynecology, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
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Article Info
Journal
Oncotarget
Abbr.
Oncotarget
ISSN
1949-2553
DOI
10.18632/oncotarget.3650
Published
2015-05-20
Pages
12174-87
Language
English
Region
United States
NLM ID
101532965
PMCID
PMC4494930
Subset
IM
External Links
PubMed source DOI: 10.18632/oncotarget.3650 PMC Full Text View journal details
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