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PMID: 19307055 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Tyrosine kinase B receptor and BDNF expression in ovarian cancers - Effect on cell migration, angiogenesis and clinical outcome.

Cancer letters ·Vol. 281 ·No. 2 ·2009-08-28 ·Pages 151-61

Au CW, Siu MK, Liao X, Wong ES, Ngan HY, Tam KF, Chan DC, Chan QK, Cheung AN

Abstract

In this report, we demonstrated that overexpression of tropomyosin-related kinase B (TrkB) was associated with shorter survival in ovarian cancer patients. Brain-derived neurotrophic factor (BDNF), the TrkB ligand, induced activation (phosphorylation) of TrkB in a dose dependent manner. Besides demonstrating the effect of BDNF/TrkB pathway in enhancing cancer cell migration and invasion but inhibiting apoptosis, we also report for the first time that exogenous hepatocyte growth factor induced TrkB expression at both mRNA and protein levels as well as phosphorylation. Our findings suggest that BDNF/TrkB pathway is important in ovarian carcinogenesis and TrkB may be a potential therapeutic target for ovarian cancer.

MeSH Terms

Adult Aged Aged, 80 and over Blotting, Western Brain-Derived Neurotrophic Factor/biosynthesis Cell Line, Tumor Cell Movement/physiology Female Gene Silencing Hepatocyte Growth Factor/metabolism Humans Immunohistochemistry Immunoprecipitation In Situ Nick-End Labeling Kaplan-Meier Estimate Middle Aged Neoplasm Invasiveness/genetics,pathology Neovascularization, Pathologic/genetics,metabolism Ovarian Neoplasms/metabolism,mortality,pathology Prognosis RNA, Messenger/analysis RNA, Small Interfering Receptor, trkB/biosynthesis Reverse Transcriptase Polymerase Chain Reaction Vascular Endothelial Growth Factor Receptor-2/metabolism Young Adult

Chemicals

Brain-Derived Neurotrophic Factor RNA, Messenger RNA, Small Interfering Hepatocyte Growth Factor Receptor, trkB Vascular Endothelial Growth Factor Receptor-2

Authors & Affiliations

9 authors, click to expand affiliations / ORCID

Au Christy W H

Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong.

Siu Michelle K Y

Liao Xiaoyun

Wong Esther S Y

Ngan Hextan Y S

Tam Kar Fai

Chan Dominic C W

Chan Queeny K Y

Cheung Annie N Y

Article Info

Journal

Cancer letters

Abbr.

Cancer Lett

ISSN

1872-7980

DOI

10.1016/j.canlet.2009.02.025

Published

2009-08-28

Pages

151-61

Language

English

Region

Ireland

NLM ID

7600053

Subset

External Links

PubMed source DOI: 10.1016/j.canlet.2009.02.025 View journal details

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Tyrosine kinase B receptor and BDNF expression in ovarian cancers - Effect on cell migration, angiogenesis and clinical outcome.

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