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PMID: 25522665 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Regulation of T cells by mTOR: the known knowns and the known unknowns.

Trends in immunology ·Vol. 36 ·No. 1 ·2015-01-00 ·Pages 13-20

Pollizzi KN, Powell JD

Abstract

Mammalian/mechanistic target of rapamycin (mTOR) is emerging as an important integrator of environmental cues critical for the regulation of T cell activation, differentiation, and function. Recent studies leveraging pharmacologic inhibition or T cell specific genetic deletion of signaling components in the mTOR pathway have provided important insights into the mechanisms involved, and have been informative in defining targets downstream of mTOR that promote immune regulation. However, these studies have also presented confusing and, at times, contradictory findings, highlighting the complexities involved in examining the mTOR pathway in distinct contexts. Here, we review current understanding of the roles of mTOR in T cell biology, highlighting emerging concepts and areas of investigation where the precise role of mTOR has yet to be fully discerned.

Keywords
T cells mTOR rapamycin
MeSH Terms
Animals CD8-Positive T-Lymphocytes/cytology,immunology,metabolism Cell Differentiation/genetics,immunology Gene Deletion Humans Lymphocyte Activation/genetics,immunology Signal Transduction T-Lymphocytes/cytology,immunology,metabolism TOR Serine-Threonine Kinases/genetics,metabolism
Chemicals
TOR Serine-Threonine Kinases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Pollizzi Kristen N
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address: kpolliz2@jhmi.edu.
Powell Jonathan D
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address: poweljo@jhmi.edu.
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Article Info
Journal
Trends in immunology
Abbr.
Trends Immunol
ISSN
1471-4981
DOI
10.1016/j.it.2014.11.005
Email
kpolliz2@jhmi.edu
poweljo@jhmi.edu
Published
2015-01-00
Epub
2014-00-16
Pages
13-20
Language
English
Region
England
NLM ID
100966032
PMCID
PMC4290883
Subset
IM
Grants
NIAID NIH HHS · R01AI077610 · United States
NIAID NIH HHS · R01 AI091481 · United States
NIAID NIH HHS · T32 AI007247 · United States
NIAID NIH HHS · R01AI091481 · United States
NIAID NIH HHS · R01 AI077610 · United States
External Links
PubMed source DOI: 10.1016/j.it.2014.11.005 PMC Full Text View journal details
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