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PMID: 24962260 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Integrating canonical and metabolic signalling programmes in the regulation of T cell responses.

Nature reviews. Immunology ·Vol. 14 ·No. 7 ·2014-07-00 ·Pages 435-46

Pollizzi KN, Powell JD

Abstract

Over the past decade, our understanding of T cell activation, differentiation and function has markedly expanded, providing a greater appreciation of the signals and pathways that regulate these processes. It has become clear that evolutionarily conserved pathways that regulate stress responses, metabolism, autophagy and survival have crucial and specific roles in regulating T cell responses. Recent studies suggest that the metabolic pathways involving MYC, hypoxia-inducible factor 1α (HIF1α), AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) are activated upon antigen recognition and that they are required for directing the consequences of T cell receptor engagement. The purpose of this Review is to provide an integrated view of the role of these metabolic pathways and of canonical T cell signalling pathways in regulating the outcome of T cell responses.

MeSH Terms
AMP-Activated Protein Kinases/immunology Animals CD8-Positive T-Lymphocytes/immunology,metabolism Cell Differentiation/immunology Glycolysis Hypoxia-Inducible Factor 1, alpha Subunit/immunology Immunologic Memory/immunology Lymphocyte Activation/immunology Mice Proto-Oncogene Proteins c-myc/immunology Receptors, Antigen, T-Cell/immunology Signal Transduction/immunology T-Lymphocytes, Helper-Inducer/immunology,metabolism T-Lymphocytes, Regulatory/immunology,metabolism TOR Serine-Threonine Kinases/immunology
Chemicals
Hif1a protein, mouse Hypoxia-Inducible Factor 1, alpha Subunit Myc protein, mouse Proto-Oncogene Proteins c-myc Receptors, Antigen, T-Cell mTOR protein, mouse TOR Serine-Threonine Kinases AMP-Activated Protein Kinases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Pollizzi Kristen N
Sidney Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
Powell Jonathan D
Sidney Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
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Article Info
Journal
Nature reviews. Immunology
Abbr.
Nat Rev Immunol
ISSN
1474-1741
DOI
10.1038/nri3701
Published
2014-07-00
Pages
435-46
Language
English
Region
England
NLM ID
101124169
PMCID
PMC4390057
Subset
IM
Grants
NCI NIH HHS · P30 CA006973 · United States
NIAID NIH HHS · R01 AI091481 · United States
NIAID NIH HHS · T32 AI007247 · United States
NIAID NIH HHS · R01AI077610‑01A2 · United States
NIAID NIH HHS · R01 AI077610 · United States
External Links
PubMed source DOI: 10.1038/nri3701 PMC Full Text View journal details
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