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PMID: 23395268 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Nutrient sensing, metabolism, and cell growth control.

Molecular cell ·Vol. 49 ·No. 3 ·2013-02-07 ·Pages 379-87

Yuan HX, Xiong Y, Guan KL

Abstract

Cell growth is regulated by coordination of both extracellular nutrients and intracellular metabolite concentrations. AMP-activated kinase and mammalian target of rapamycin complex 1 serve as key molecules that sense cellular energy and nutrients levels, respectively. In addition, the members of the dioxygenase family, including prolylhydroxylase, lysine demethylase, and DNA demethylase, have emerged as possible sensors of intracellular metabolic status. The interplay among nutrients, metabolites, gene expression, and protein modification are involved in the coordination of cell growth with extracellular and intracellular conditions.

MeSH Terms
AMP-Activated Protein Kinases/metabolism Animals Cell Proliferation Cells/enzymology,metabolism Epigenesis, Genetic Humans Metabolic Networks and Pathways/genetics Signal Transduction/genetics
Chemicals
AMP-Activated Protein Kinases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Yuan Hai-Xin
Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
Xiong Yue
Guan Kun-Liang
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Article Info
Journal
Molecular cell
Abbr.
Mol Cell
ISSN
1097-4164
DOI
10.1016/j.molcel.2013.01.019
Published
2013-02-07
Pages
379-87
Language
English
Region
United States
NLM ID
9802571
PMCID
PMC3587157
Subset
IM
Grants
NCI NIH HHS · R01 CA108941 · United States
NCI NIH HHS · R01 CA132809 · United States
External Links
PubMed source DOI: 10.1016/j.molcel.2013.01.019 PMC Full Text View journal details
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