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PMID: 25488198 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Cadherins in tissue architecture and disease.

Journal of molecular medicine (Berlin, Germany) ·Vol. 93 ·No. 1 ·2015-01-00 ·Pages 5-11

Vestweber D

Abstract

Cadherins are homophilic cell adhesion molecules that determine tissue architecture and control cell contact formation and dissociation in development and tissue homeostasis of all metazoans. These adhesion molecules mediate homophilic interactions between cells and are linked inside the cell via a complex set of cytosolic factors to the actin cytoskeleton. These interactions are key to the plasticity of intercellular junctions and to the various signaling functions of the cadherins. This forms the basis for cadherin-driven cell behavior, cell differentiation, and regeneration of tissue structures. Consequently, mutations in cadherins are the cause of various human pathologies, with cancer representing one of the most prominent examples.

MeSH Terms
Animals Cadherins/chemistry,physiology Cell Adhesion Disease Humans Mechanotransduction, Cellular Neoplasms/metabolism Protein Conformation
Chemicals
Cadherins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Vestweber Dietmar
Max Planck Institute for Molecular Biomedicine, Röntgenstr. 20, 48149, Münster, Germany, vestweb@mpi-muenster.mpg.de.
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Article Info
Journal
Journal of molecular medicine (Berlin, Germany)
Abbr.
J Mol Med (Berl)
ISSN
1432-1440
DOI
10.1007/s00109-014-1231-5
Email
vestweb@mpi-muenster.mpg.de
Published
2015-01-00
Epub
2014-00-10
Pages
5-11
Language
English
Region
Germany
NLM ID
9504370
Subset
IM
External Links
PubMed source DOI: 10.1007/s00109-014-1231-5 View journal details
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