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PMID: 2547487 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Postjunctional alpha 2-adrenoceptors mediate vasoconstriction in human subcutaneous resistance vessels.

British journal of pharmacology ·Vol. 97 ·No. 3 ·1989-07-00 ·Pages 829-34

Nielsen H, Thom SM, Hughes AD, Martin GN, Mulvany MJ, Sever PS

Abstract

1. In vitro studies have been performed on human medium-sized muscular arteries (internal diameter 1-4 mm) in a classical organ bath and with human subcutaneous resistance arteries (internal diameter 103-626 microns) in a microvascular myograph. 2. Although the medium-sized muscular arteries showed no response to either of the alpha 2-agonists B-HT 933 or UK 14304 in concentrations up to 10 microM, the subcutaneous resistance arteries from all regions examined showed well-pronounced and concentration-dependent responses to B-HT 933, the pD2 (-log EC50) being 5.11 +/- 0.09. 3. In the resistance arteries the alpha 2-antagonist yohimbine caused a parallel shift to the right of the B-HT 933 concentration-response curve; the yohimbine pA2 for the B-HT 933 receptor was 7.86 +/- 0.12. 4. There was an inverse relationship between the maximum response to B-HT 933 and the calibre of the resistance vessels. 5. These results indicate the presence of a postjunctional alpha 2-adrenoceptor in human subcutaneous resistance arteries and not in medium sized muscular arteries.

MeSH Terms
Adult Aged Aged, 80 and over Antihypertensive Agents/pharmacology Arteries/drug effects Azepines/pharmacology Brimonidine Tartrate Doxazosin Female Humans In Vitro Techniques Male Middle Aged Norepinephrine/pharmacology Prazosin/analogs & derivatives,pharmacology Quinoxalines/pharmacology Receptors, Adrenergic, alpha/physiology Regional Blood Flow/drug effects Skin/blood supply Vascular Resistance/drug effects Vasoconstriction Veins/drug effects Yohimbine/pharmacology
Chemicals
Antihypertensive Agents Azepines Quinoxalines Receptors, Adrenergic, alpha Yohimbine Brimonidine Tartrate azepexole Doxazosin Norepinephrine Prazosin
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Nielsen H
Department of Clinical Pharmacology, Queen Elisabeth The Queen Mother Wing, St. Mary's Hospital, London.
Thom S M
Hughes A D
Martin G N
Mulvany M J
Sever P S
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Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
0007-1188
DOI
10.1111/j.1476-5381.1989.tb12022.x
Published
1989-07-00
Pages
829-34
Language
English
Region
England
NLM ID
7502536
PMCID
PMC1854570
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1989.tb12022.x PMC Full Text View journal details
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