Abstract
It has been reported that miR-19a was up-regulated in gastric cancer (GC), playing an oncogenic role. However, the underlying mechanism is still unknown. Therefore, in our present study, we investigated the role of miR-19a in gastric tissues as well as 2 GC cell lines. In vivo in clinical tissue level, we have detected basal expression level of miR-19a using real-time reversal transcriptional PCR (RT-PCR); in addition, the relevance between expression of miR-19a and clinic-pathological information was also analyzed. In vitro in cell line level, miR-19a was ectopically expressed using over expression and knock-down strategy. It was found that the overexpression of miR-19a was significantly associated with metastasis of GC and inferior overall prognosis on clinical tissue level; that promotes the proliferation, migration and invasion; and that overexpression of miR-19a can promote the epithelial-mesenchymal transition through activating PI3K/AKT pathway. Blocking the PI3K/AKT pathway could cancel the effect of miR-19a. All together, our results suggest that miR-19a could be used as a promising therapeutic target in the treatment of GC.
Keywords
EMT
Gastric cancer
PI3K-AKT
miR-19a
MeSH Terms
Cell Line, Tumor
Cell Movement
Cell Proliferation
Enzyme Activation
Epithelial-Mesenchymal Transition/drug effects
Female
Humans
Male
MicroRNAs/genetics,metabolism
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Phenotype
Phosphatidylinositol 3-Kinase/metabolism
Phosphoinositide-3 Kinase Inhibitors
Protein Kinase Inhibitors/pharmacology
Proto-Oncogene Proteins c-akt/antagonists & inhibitors,genetics,metabolism
RNA Interference
Signal Transduction
Stomach Neoplasms/enzymology,genetics,pathology
Time Factors
Transfection
Chemicals
MIRN19 microRNA, human
MicroRNAs
Phosphoinositide-3 Kinase Inhibitors
Protein Kinase Inhibitors
Phosphatidylinositol 3-Kinase
Proto-Oncogene Proteins c-akt
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Lu Weidong
Department of Oncology, Zhangjiagang First People's Hospital, Suzhou University Zhangjiagang 215600, China.
Xu Zhen
Department of Oncology, Zhangjiagang First People's Hospital, Suzhou University Zhangjiagang 215600, China.
Zhang Min
Department of Oncology, Zhangjiagang First People's Hospital, Suzhou University Zhangjiagang 215600, China.
Zuo Yun
Department of Oncology, Zhangjiagang First People's Hospital, Suzhou University Zhangjiagang 215600, China.
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