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PMID: 2538722 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

An AP-2 element acts synergistically with the cyclic AMP- and phorbol ester-inducible enhancer of the human proenkephalin gene.

Molecular and cellular biology ·Vol. 9 ·No. 1 ·1989-01-00 ·Pages 321-4

Hyman SE, Comb M, Pearlberg J, Goodman HM

Abstract

An enhancer with two DNA elements, one containing the sequence CGTCA, is required for cyclic AMP- and phorbol ester-inducible transcription of the human proenkephalin gene. We report that an AP-2 element located adjacent to the enhancer acts synergistically with it to confer maximal response to cyclic AMP and phorbol esters.

MeSH Terms

Base Sequence Cyclic AMP/genetics,metabolism DNA/analysis DNA-Binding Proteins/genetics Deoxyribonuclease I Enhancer Elements, Genetic/drug effects Enkephalins/genetics,metabolism Humans Mutation Phorbol Esters/pharmacology Promoter Regions, Genetic Protein Precursors/genetics,metabolism

Chemicals

DNA-Binding Proteins Enkephalins Phorbol Esters Protein Precursors proenkephalin DNA Cyclic AMP Deoxyribonuclease I

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Hyman S E

Department of Molecular Biology, Massachusetts General Hospital, Boston 02114.

Comb M

Pearlberg J

Goodman H M

References (18)

18 references, click to expand

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A cyclic AMP- and phorbol ester-inducible DNA element.
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Article Info

Journal

Molecular and cellular biology

Abbr.

Mol Cell Biol

ISSN

0270-7306

DOI

10.1128/mcb.9.1.321-324.1989

Published

1989-01-00

Pages

321-4

Language

English

Region

United States

NLM ID

8109087

PMCID

PMC362175

Subset

External Links

PubMed source DOI: 10.1128/mcb.9.1.321-324.1989 PMC Full Text View journal details

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An AP-2 element acts synergistically with the cyclic AMP- and phorbol ester-inducible enhancer of the human proenkephalin gene.

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