Distinct factors bind the AP-1 consensus sites in gibbon ape leukemia virus and simian virus 40 enhancers.

Journal of virology ·Vol. 63 ·No. 4 ·1989-04-00 ·Pages 1737-42

Quinn JP, Takimoto M, Iadarola M, Holbrook N, Levens D

Abstract

We have demonstrated that the gibbon ape leukemia virus (GALV) enhancer AP-1 element and the simian virus 40 AP-1 enhancer element bind different factors in HeLa nuclear extracts. A 39-kilodalton HeLa nuclear protein and the c-fos protein bind to the GALV element. Antibodies to c-fos abolish binding to the GALV AP-1 site. In contrast, anti-c-fos immunoglobulin fails to inhibit formation of the simian virus 40-specific complex from extracts of HeLa cells. Thus, AP-1-binding complexes are subject to compositional variation at different binding sites.

MeSH Terms

Animals Cell Line DNA, Viral/metabolism DNA-Binding Proteins/isolation & purification,metabolism Enhancer Elements, Genetic Humans Hylobates Immunologic Techniques Protein Binding Proto-Oncogene Proteins/genetics Proto-Oncogene Proteins c-fos Regulatory Sequences, Nucleic Acid Retroviridae/genetics Simian virus 40/genetics Transcription Factors/isolation & purification,metabolism

Chemicals

DNA, Viral DNA-Binding Proteins Proto-Oncogene Proteins Proto-Oncogene Proteins c-fos Transcription Factors

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Quinn J P

Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland.

Takimoto M

Iadarola M

Holbrook N

Levens D

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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.63.4.1737-1742.1989

Published

1989-04-00

Pages

1737-42

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC248435

Subset

External Links

PubMed source DOI: 10.1128/JVI.63.4.1737-1742.1989 PMC Full Text View journal details

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Distinct factors bind the AP-1 consensus sites in gibbon ape leukemia virus and simian virus 40 enhancers.

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